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Literature summary for 3.2.1.207 extracted from

  • Stigliano, I.D.; Alculumbre, S.G.; Labriola, C.A.; Parodi, A.J.; DAlessio, C.
    Glucosidase II and N-glycan mannose content regulate the half-lives of monoglucosylated species in vivo (2011), Mol. Biol. Cell, 22, 1810-1823.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.207

Protein Variants

Protein Variants Comment Organism
E114A inactive towards Glc1Man9GlcNAc2 Schizosaccharomyces pombe
E114A inactive towards Glc1Man9GlcNAc2 Leishmania mexicana
E73A inactive towards Glc1Man9GlcNAc2 Schizosaccharomyces pombe
E73A inactive towards Glc1Man9GlcNAc2 Leishmania mexicana

Inhibitors

Inhibitors Comment Organism Structure
1-deoxynojirimycin
-
 Leishmania mexicana
1-deoxynojirimycin
-
 Schizosaccharomyces pombe

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Schizosaccharomyces pombe 5783
-
endoplasmic reticulum
-
 Leishmania mexicana 5783
-

Organism

Organism UniProt Comment Textmining
Leishmania mexicana
-
-
-
Schizosaccharomyces pombe
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GlcNAcalpha(1->3)GlcNAcalpha(1->3)Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc + H2O
-
 Schizosaccharomyces pombe GlcNAcalpha(1->3)Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc + D-glucose
-
 ?
GlcNAcalpha(1->3)GlcNAcalpha(1->3)Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc + H2O
-
 Leishmania mexicana GlcNAcalpha(1->3)Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc + D-glucose
-
 ?
GlcNAcalpha(1->3)Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc + H2O
-
 Schizosaccharomyces pombe Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc + D-glucose
-
 ?
GlcNAcalpha(1->3)Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc + H2O
-
 Leishmania mexicana Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc + D-glucose
-
 ?

Subunits

Subunits Comment Organism
heterodimer the alpha subunit bears the active site, and the beta subunit modulates the subunit alpha activity through its C-terminal mannose 6-phosphate receptor homologous domain Schizosaccharomyces pombe
heterodimer the alpha subunit bears the active site, and the beta subunit modulates the subunit alpha activity through its C-terminal mannose 6-phosphate receptor homologous domain Leishmania mexicana

Synonyms

Synonyms Comment Organism
GII
-
 Schizosaccharomyces pombe
GII
-
 Leishmania mexicana
glucosidase II
-
 Schizosaccharomyces pombe
glucosidase II
-
 Leishmania mexicana

Expression

Organism Comment Expression
Schizosaccharomyces pombe in live Schizosaccharomyces pombe cells, a decrease in the number of mannoses in the glycan results in decreased glucosidase II activity down
Leishmania mexicana in live Schizosaccharomyces pombe cells, a decrease in the number of mannoses in the glycan results in decreased glucosidase II activity down