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Literature summary for 3.2.1.207 extracted from

  • Totani, K.; Ihara, Y.; Matsuo, I.; Ito, Y.
    Effects of macromolecular crowding on glycoprotein processing enzymes (2008), J. Am. Chem. Soc., 130, 2101-2107.
    View publication on PubMed
Search for more literature for 3.2.1.207

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
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 Rattus norvegicus 5783
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Glc2Man9GlcNAc2 (G2M9)-protein + H2O Rattus norvegicus glucosidase II plays a key role in glycoprotein processing in the endoplasmic reticulum. This enzyme trims two alpha-1,3-linked glucose residues, Glcalpha1,3Glc (cleavage 1) and Glcalpha1,3Man (cleavage 2) from high-mannose type Glc2Man9GlcNAc2 (G2M9)-proteins. A crowded milieu that contains bovine serum albumin greatly enhances the second trimming step (cleavage 2), which deglucosylates Glc1Man9GlcNAc2, but not the first trimming step (cleavage 1), which removes the terminal glucose residue from Glc2Man9GlcNAc2 ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl alpha-D-glucopyranoside + H2O
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 Rattus norvegicus 4-nitrophenol + D-glucose
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 ?
Glc2Man9GlcNAc2 (G2M9)-protein + H2O glucosidase II plays a key role in glycoprotein processing in the endoplasmic reticulum. This enzyme trims two alpha-1,3-linked glucose residues, Glcalpha1,3Glc (cleavage 1) and Glcalpha1,3Man (cleavage 2) from high-mannose type Glc2Man9GlcNAc2 (G2M9)-proteins. A crowded milieu that contains bovine serum albumin greatly enhances the second trimming step (cleavage 2), which deglucosylates Glc1Man9GlcNAc2, but not the first trimming step (cleavage 1), which removes the terminal glucose residue from Glc2Man9GlcNAc2 Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
glucosidase II
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 Rattus norvegicus