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Literature summary for 3.2.1.20 extracted from

  • Jhong, C.; Riyaphan, J.; Lin, S.; Chia, Y.; Weng, C.
    Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico (2015), Biofactors, 41, 242-251 .
    View publication on PubMed
Search for more literature for 3.2.1.20

Inhibitors

Inhibitors Comment Organism Structure
16-hydroxy-cleroda-3,13-dine-16,15-olide 25% inhibition at 0.1 mM Homo sapiens
4'-(4-toluenesulfonamide)-3,4-dihydroxychalcone
-
 Homo sapiens
4'-amino-4-hydroxychalcone
-
 Homo sapiens
acarbose
-
 Homo sapiens
actinodaphnine 26% inhibition at 0.1 mM Homo sapiens
antroquinonol 7% inhibition at 0.1 mM Homo sapiens
Berberine 16% inhibition at 0.1 mM Homo sapiens
catechin 10% inhibition at 0.1 mM Homo sapiens
curcumin 60% inhibition at 0.1 mM Homo sapiens
docosanol 3% inhibition at 0.1 mM Homo sapiens
eupafolin
-
 Homo sapiens
fisetin
-
 Homo sapiens
luteolin
-
 Homo sapiens
additional information not inhibited by rutin Homo sapiens
myricetin
-
 Homo sapiens
quercetin 18% inhibition at 0.1 mM Homo sapiens
tetracosanol 1% inhibition at 0.1 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl alpha-D-glucoside + H2O
-
 Homo sapiens 4-nitrophenol + alpha-D-glucose
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000996
-
 at pH 6.8 and 37°C Homo sapiens acarbose
0.0184
-
 at pH 6.8 and 37°C Homo sapiens luteolin
0.0196
-
 at pH 6.8 and 37°C Homo sapiens fisetin
0.0214
-
 at pH 6.8 and 37°C Homo sapiens quercetin
0.0302
-
 at pH 6.8 and 37°C Homo sapiens myricetin
0.048
-
 at pH 6.8 and 37°C Homo sapiens eupafolin
0.1937
-
 at pH 6.8 and 37°C Homo sapiens 4'-amino-4-hydroxychalcone
0.2689
-
 at pH 6.8 and 37°C Homo sapiens 4'-(4-toluenesulfonamide)-3,4-dihydroxychalcone