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Literature summary for 3.2.1.20 extracted from
- Triterpene acids isolated from Lagerstroemia speciosa leaves as alpha-glucosidase inhibitors (2008), Phytother. Res., 23, 614-618.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 23-hydroxyursolic acid | triterpene acid isolated from Lagerstroemia speciosa leaves, moderate inhibitory activity | Saccharomyces cerevisiae |  |
| arjunolic acid | triterpene acid isolated from Lagerstroemia speciosa leaves, moderate inhibitory activity | Saccharomyces cerevisiae | |
| asiatic acid | triterpene acid isolated from Lagerstroemia speciosa leaves, moderate inhibitory activity | Saccharomyces cerevisiae | |
| corosolic acid | triterpene acid isolated from Lagerstroemia speciosa leaves, shows best bioactivity | Saccharomyces cerevisiae | |
| maslinic acid | triterpene acid isolated from Lagerstroemia speciosa leaves, moderate inhibitory activity | Saccharomyces cerevisiae | |
| additional information | no inhibition with acarbose or voglibose | Saccharomyces cerevisiae | |
| oleanolic acid | triterpene acid isolated from Lagerstroemia speciosa leaves, moderate inhibitory activity | Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl alpha-D-glucopyranoside + H2O | - |
Saccharomyces cerevisiae | 4-nitrophenol + alpha-D-glucopyranose | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-glucosidase | - |
Saccharomyces cerevisiae |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| additional information | - |
IC50: 3.53 microg/ml for corosolic acid, 88.72 microg/ml for ethyl acetate extract, 6.29 microg/ml for oleanolic acid, 18.63 microg/ml for arjunolic acid, 30.03 microg/ml for asiatic acid, 5.52 microg/ml for maslinic acid, 8.14 microg/ml for 23-hydroxyursolic acid | Saccharomyces cerevisiae | additional information |
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Release 2023.1 (January 2023)
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