Application | Comment | Organism |
---|---|---|
medicine | inhibitors of alpha-glucosidase are promising candidates for the development of antitype II diabetics and anti-AIDS drugs | Saccharomyces cerevisiae |
medicine | inhibitors of alpha-glucosidase are promising candidates for the development of antitype II diabetics and anti-AIDS drugs | Geobacillus stearothermophilus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,2'R,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Geobacillus stearothermophilus | |
(2R,2'R,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Saccharomyces cerevisiae | |
(2R,2'S,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Geobacillus stearothermophilus | |
(2R,2'S,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Saccharomyces cerevisiae | |
(2R,7R,8R,9R)-8,9-dihydroxy-2-octyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Geobacillus stearothermophilus | |
(2R,7R,8R,9R)-8,9-dihydroxy-2-octyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Saccharomyces cerevisiae | |
(2S,2'R,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Geobacillus stearothermophilus | |
(2S,2'R,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Saccharomyces cerevisiae | |
(2S,2'S,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Geobacillus stearothermophilus | |
(2S,2'S,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Saccharomyces cerevisiae | |
(2S,7R,8R,9R)-8,9-dihydroxy-2-octyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Geobacillus stearothermophilus | |
(2S,7R,8R,9R)-8,9-dihydroxy-2-octyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Saccharomyces cerevisiae | |
(6aS,12aR)-5,5-dimethyl-5,6a,7,12a-tetrahydroisochromeno[4,3-b]chromene-3,4,8,10-tetrol | - |
Geobacillus stearothermophilus | |
(6aS,12aR)-5,5-dimethyl-5,6a,7,12a-tetrahydroisochromeno[4,3-b]chromene-3,4,8,10-tetrol | - |
Saccharomyces cerevisiae | |
(7R,8R,9R)-2,2-dihexyl-8,9-dihydroxy-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Geobacillus stearothermophilus | |
(7R,8R,9R)-2,2-dihexyl-8,9-dihydroxy-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Saccharomyces cerevisiae | |
(7R,8R,9R)-8,9-dihydroxy-4-oxo-2,2-dipentyl-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Geobacillus stearothermophilus | |
(7R,8R,9R)-8,9-dihydroxy-4-oxo-2,2-dipentyl-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | - |
Saccharomyces cerevisiae | |
1,7-(3-pentanone) 3,4-(3-pentanone)-chlorogenic acid diketal | - |
Geobacillus stearothermophilus | |
1,7-(3-pentanone) 3,4-(3-pentanone)-chlorogenic acid diketal | - |
Saccharomyces cerevisiae | |
1,7-(3-pentanone) chlorogenic acid ketal | - |
Geobacillus stearothermophilus | |
1,7-(3-pentanone) chlorogenic acid ketal | - |
Saccharomyces cerevisiae | |
1,7-(4-heptanone) 3,4-(4-heptanone)-chlorogenic acid diketal | - |
Geobacillus stearothermophilus | |
1,7-(4-heptanone) 3,4-(4-heptanone)-chlorogenic acid diketal | - |
Saccharomyces cerevisiae | |
1,7-(4-heptanone) chlorogenic acid ketal | - |
Geobacillus stearothermophilus | |
1,7-(4-heptanone) chlorogenic acid ketal | - |
Saccharomyces cerevisiae | |
1,7-(5-nonanone) 3,4-(5-nonanone)-chlorogenic acid diketal | - |
Geobacillus stearothermophilus | |
1,7-(5-nonanone) 3,4-(5-nonanone)-chlorogenic acid diketal | - |
Saccharomyces cerevisiae | |
1,7-(5-nonanone) chlorogenic acid ketal | - |
Geobacillus stearothermophilus | |
1,7-(5-nonanone) chlorogenic acid ketal | - |
Saccharomyces cerevisiae | |
1,7-(6-undecanone) 3,4-(6-undecanone)-chlorogenic acid diketal | - |
Geobacillus stearothermophilus | |
1,7-(6-undecanone) 3,4-(6-undecanone)-chlorogenic acid diketal | - |
Saccharomyces cerevisiae | |
1,7-(8-pentadecanone) chlorogenic acid ketal | - |
Geobacillus stearothermophilus | |
1,7-(8-pentadecanone) chlorogenic acid ketal | - |
Saccharomyces cerevisiae | |
1,7-(9-heptadecanone) 3,4-(9-heptadecanone)-chlorogenic acid diketal | - |
Geobacillus stearothermophilus | |
1,7-(9-heptadecanone) 3,4-(9-heptadecanone)-chlorogenic acid diketal | - |
Saccharomyces cerevisiae | |
1,7-(9-heptadecanone) chlorogenic acid ketal | - |
Geobacillus stearothermophilus | |
1,7-(9-heptadecanone) chlorogenic acid ketal | - |
Saccharomyces cerevisiae | |
1,7-(acetone) 3,4-(acetone)-chlorogenic acid diketal | - |
Geobacillus stearothermophilus | |
1,7-(acetone) 3,4-(acetone)-chlorogenic acid diketal | - |
Saccharomyces cerevisiae | |
1,7-(acetone) chlorogenic acid ketal | - |
Geobacillus stearothermophilus | |
1,7-(acetone) chlorogenic acid ketal | - |
Saccharomyces cerevisiae | |
1,7-(diheptyl ketone) 3,4-(diheptyl ketone)-chlorogenic acid diketal | - |
Geobacillus stearothermophilus | |
1,7-(diheptyl ketone) 3,4-(diheptyl ketone)-chlorogenic acid diketal | - |
Saccharomyces cerevisiae | |
1,7-(dihexyl ketone) 3,4-(dihexyl ketone)-chlorogenic acid diketal | - |
Geobacillus stearothermophilus | |
1,7-(dihexyl ketone) 3,4-(dihexyl ketone)-chlorogenic acid diketal | - |
Saccharomyces cerevisiae | |
1-deoxynojirimycin hydrochloride | - |
Geobacillus stearothermophilus | |
1-deoxynojirimycin hydrochloride | - |
Saccharomyces cerevisiae | |
acarbose | - |
Geobacillus stearothermophilus | |
acarbose | - |
Saccharomyces cerevisiae | |
chlorogenic acid | - |
Geobacillus stearothermophilus | |
chlorogenic acid | - |
Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Saccharomyces cerevisiae | alpha-glucosidases play important roles in the digestion of carbohydrates and biosynthesis of viral envelope glycoproteins | ? | - |
? | |
additional information | Geobacillus stearothermophilus | alpha-glucosidases play important roles in the digestion of carbohydrates and biosynthesis of viral envelope glycoproteins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Geobacillus stearothermophilus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl alpha-D-glucopyranoside + H2O | - |
Saccharomyces cerevisiae | 4-nitrophenol + alpha-D-glucopyranose | - |
? | |
4-nitrophenyl alpha-D-glucopyranoside + H2O | - |
Geobacillus stearothermophilus | 4-nitrophenol + alpha-D-glucopyranose | - |
? | |
additional information | alpha-glucosidases play important roles in the digestion of carbohydrates and biosynthesis of viral envelope glycoproteins | Saccharomyces cerevisiae | ? | - |
? | |
additional information | alpha-glucosidases play important roles in the digestion of carbohydrates and biosynthesis of viral envelope glycoproteins | Geobacillus stearothermophilus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-glucosidase | - |
Saccharomyces cerevisiae |
alpha-glucosidase | - |
Geobacillus stearothermophilus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0001 | - |
- |
Saccharomyces cerevisiae | acarbose | |
0.0001 | - |
- |
Geobacillus stearothermophilus | acarbose | |
0.0003 | - |
- |
Saccharomyces cerevisiae | (2R,2'R,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0003 | - |
- |
Saccharomyces cerevisiae | (2S,2'R,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0003 | - |
- |
Saccharomyces cerevisiae | 1,7-(5-nonanone) 3,4-(5-nonanone)-chlorogenic acid diketal | |
0.0004 | - |
- |
Saccharomyces cerevisiae | 1,7-(diheptyl ketone) 3,4-(diheptyl ketone)-chlorogenic acid diketal | |
0.0005 | - |
- |
Saccharomyces cerevisiae | 1,7-(dihexyl ketone) 3,4-(dihexyl ketone)-chlorogenic acid diketal | |
0.0005 | - |
- |
Saccharomyces cerevisiae | 1,7-(9-heptadecanone) 3,4-(9-heptadecanone)-chlorogenic acid diketal | |
0.0007 | - |
- |
Geobacillus stearothermophilus | (2S,2'R,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0008 | - |
- |
Geobacillus stearothermophilus | (2R,2'R,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0008 | - |
- |
Saccharomyces cerevisiae | (2S,2'S,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0008 | - |
- |
Geobacillus stearothermophilus | 1,7-(5-nonanone) 3,4-(5-nonanone)-chlorogenic acid diketal | |
0.0008 | - |
- |
Saccharomyces cerevisiae | 1,7-(6-undecanone) 3,4-(6-undecanone)-chlorogenic acid diketal | |
0.0008 | - |
- |
Geobacillus stearothermophilus | 1,7-(dihexyl ketone) 3,4-(dihexyl ketone)-chlorogenic acid diketal | |
0.0009 | - |
- |
Geobacillus stearothermophilus | 1,7-(diheptyl ketone) 3,4-(diheptyl ketone)-chlorogenic acid diketal | |
0.0009 | - |
- |
Geobacillus stearothermophilus | 1,7-(9-heptadecanone) 3,4-(9-heptadecanone)-chlorogenic acid diketal | |
0.001 | - |
- |
Saccharomyces cerevisiae | (2R,2'S,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0011 | - |
- |
Geobacillus stearothermophilus | 1,7-(6-undecanone) 3,4-(6-undecanone)-chlorogenic acid diketal | |
0.0018 | - |
- |
Geobacillus stearothermophilus | (2S,2'S,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0018 | - |
- |
Saccharomyces cerevisiae | 1-deoxynojirimycin hydrochloride | |
0.002 | - |
- |
Geobacillus stearothermophilus | (2R,2'S,7R)-2,2'-dioctyl-5'-oxotetrahydro-4H-spiro[1,3-benzodioxole-5,4'-[1,3]dioxolan]-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0024 | - |
- |
Geobacillus stearothermophilus | 1-deoxynojirimycin hydrochloride | |
0.003 | - |
- |
Saccharomyces cerevisiae | 1,7-(9-heptadecanone) chlorogenic acid ketal | |
0.0033 | - |
- |
Saccharomyces cerevisiae | (2S,7R,8R,9R)-8,9-dihydroxy-2-octyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0033 | - |
- |
Saccharomyces cerevisiae | 1,7-(4-heptanone) 3,4-(4-heptanone)-chlorogenic acid diketal | |
0.0034 | - |
- |
Saccharomyces cerevisiae | (7R,8R,9R)-2,2-dihexyl-8,9-dihydroxy-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0034 | - |
- |
Saccharomyces cerevisiae | 1,7-(5-nonanone) chlorogenic acid ketal | |
0.0036 | - |
- |
Saccharomyces cerevisiae | (2R,7R,8R,9R)-8,9-dihydroxy-2-octyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0036 | - |
- |
Saccharomyces cerevisiae | (7R,8R,9R)-8,9-dihydroxy-4-oxo-2,2-dipentyl-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0036 | - |
- |
Geobacillus stearothermophilus | 1,7-(8-pentadecanone) chlorogenic acid ketal | |
0.0039 | - |
- |
Geobacillus stearothermophilus | (7R,8R,9R)-2,2-dihexyl-8,9-dihydroxy-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0043 | - |
- |
Saccharomyces cerevisiae | 1,7-(8-pentadecanone) chlorogenic acid ketal | |
0.0051 | - |
- |
Geobacillus stearothermophilus | 1,7-(9-heptadecanone) chlorogenic acid ketal | |
0.0055 | - |
- |
Geobacillus stearothermophilus | 1,7-(4-heptanone) 3,4-(4-heptanone)-chlorogenic acid diketal | |
0.0109 | - |
- |
Geobacillus stearothermophilus | (2S,7R,8R,9R)-8,9-dihydroxy-2-octyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0125 | - |
- |
Geobacillus stearothermophilus | (2R,7R,8R,9R)-8,9-dihydroxy-2-octyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0142 | - |
- |
Geobacillus stearothermophilus | (7R,8R,9R)-8,9-dihydroxy-4-oxo-2,2-dipentyl-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
0.0144 | - |
- |
Geobacillus stearothermophilus | 1,7-(5-nonanone) chlorogenic acid ketal | |
0.0185 | - |
- |
Saccharomyces cerevisiae | (6aS,12aR)-5,5-dimethyl-5,6a,7,12a-tetrahydroisochromeno[4,3-b]chromene-3,4,8,10-tetrol | |
0.0194 | - |
- |
Saccharomyces cerevisiae | 1,7-(4-heptanone) chlorogenic acid ketal | |
0.0265 | - |
- |
Saccharomyces cerevisiae | 1,7-(3-pentanone) 3,4-(3-pentanone)-chlorogenic acid diketal | |
0.0296 | - |
- |
Geobacillus stearothermophilus | (6aS,12aR)-5,5-dimethyl-5,6a,7,12a-tetrahydroisochromeno[4,3-b]chromene-3,4,8,10-tetrol | |
0.0449 | - |
- |
Geobacillus stearothermophilus | 1,7-(3-pentanone) 3,4-(3-pentanone)-chlorogenic acid diketal | |
0.0622 | - |
- |
Geobacillus stearothermophilus | 1,7-(4-heptanone) chlorogenic acid ketal | |
0.0711 | - |
- |
Saccharomyces cerevisiae | 1,7-(3-pentanone) chlorogenic acid ketal | |
0.1142 | - |
- |
Saccharomyces cerevisiae | 1,7-(acetone) chlorogenic acid ketal | |
0.1278 | - |
- |
Geobacillus stearothermophilus | 1,7-(3-pentanone) chlorogenic acid ketal | |
0.1542 | - |
- |
Geobacillus stearothermophilus | 1,7-(acetone) 3,4-(acetone)-chlorogenic acid diketal | |
0.3913 | - |
- |
Saccharomyces cerevisiae | 1,7-(acetone) 3,4-(acetone)-chlorogenic acid diketal | |
2.536 | - |
- |
Geobacillus stearothermophilus | 1,7-(acetone) chlorogenic acid ketal | |
2.822 | - |
- |
Geobacillus stearothermophilus | chlorogenic acid | |
2.822 | - |
above | Saccharomyces cerevisiae | chlorogenic acid |