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Literature summary for 3.2.1.18 extracted from

  • Shiozaki, K.; Ryuzono, S.; Matsushita, N.; Ikeda, A.; Takeshita, K.; Chigwechokha, P.K.; Komatsu, M.; Miyagi, T.
    Molecular cloning and biochemical characterization of medaka (Oryzias latipes) lysosomal neu4 sialidase (2014), Fish Physiol. Biochem., 40, 1461-1472.
    View publication on PubMed
Search for more literature for 3.2.1.18

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Oryzias latipes

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Oryzias latipes 5764
-
mitochondrion
-
 Oryzias latipes 5739
-

Organism

Organism UniProt Comment Textmining
Oryzias latipes L0N7M7 medaka
-

Source Tissue

Source Tissue Comment Organism Textmining
brain highest expression Oryzias latipes
-
embryo
-
 Oryzias latipes
-
liver
-
 Oryzias latipes
-
muscle
-
 Oryzias latipes
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-sialyllactose + H2O
-
 Oryzias latipes sialic acid + ?
-
 ?
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
-
 Oryzias latipes 4-methylumbelliferone + N-acetylneuraminic acid
-
 ?
6'-sialyllactose + H2O
-
 Oryzias latipes sialic acid + lactose
-
 ?
additional information no activity with mucin, colominic acid, gangliosides and fetuin Oryzias latipes ?
-
 ?

Synonyms

Synonyms Comment Organism
NEU4
-
 Oryzias latipes
sialidase 4
-
 Oryzias latipes

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Oryzias latipes

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6
-
-
 Oryzias latipes

pH Range

pH Minimum pH Maximum Comment Organism
8
-
 the enzyme shows broad pH specificity of sialidase activity even at neutral and alkaline pH with 30% activity remaining at pH 8.0 Oryzias latipes

Expression

Organism Comment Expression
Oryzias latipes the enzyme is upregulated at late developmental stage in embryo up