Protein Variants | Comment | Organism |
---|---|---|
additional information | replacement of the F protein of parainfluenza virus 5 major domains, M1, M2, M3, and M4, and five minor domains, A to E, in the middle region of the PIV5 F protein with the simian virus 41, SV41, F counterparts individually or in combination. A chimera designated M(1+2), which harbored SV41 F-derived domains M1 and M2, mediates cell-cell fusion with the coexpressed SV41 hemagglutinin-neuraminidase protein, suggesting that these domains are involved in determining the hemagglutinin-neuraminidase protein specificity. Another chimera which harbors the SV41 F-derived domain B in addition to domains M1 and M2 shows increased specificity for the SV41 hemagglutinin-neuraminidase protein compared to that of M(1+2), although it is capable of mediating cell-cell fusion by itself | Mammalian orthorubulavirus 5 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalian orthorubulavirus 5 | - |
PIV5 | - |
Subunits | Comment | Organism |
---|---|---|
trimer | four major domains, M1, M2, M3, and M4, and five minor domains, A to E, in the middle region of the PIV5 F protein are exposed on the trimer surface | Mammalian orthorubulavirus 5 |
Synonyms | Comment | Organism |
---|---|---|
neuraminidase | - |
Mammalian orthorubulavirus 5 |
General Information | Comment | Organism |
---|---|---|
additional information | the amino terminal region of the PIV5 hemagglutinin-neuraminidase protein determines the F protein specificity in promoting cell-cell fusion | Mammalian orthorubulavirus 5 |
physiological function | the middle region of the HPIV2 F protein contains the site(s) that determines its specificity for the HPIV2 hemagglutinin-neuraminidase protein | Mammalian orthorubulavirus 5 |