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Literature summary for 3.2.1.18 extracted from
- A single amino acid substitution in the haemagglutinin-neuraminidase protein of Newcastle disease virus results in increased fusion promotion and decreased neuraminidase activities without changes in virus pathotype (2011), J. Gen. Virol., 92, 544-551.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| development of a reverse genetics system for the generation of recombinant viruses of the NDV Anhinga strain | Avian orthoavulavirus 1 |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| I192M | naturally occuring mutant with a single nucleotide mutation T-A at position 576, isolation of a NDV variant with highly increased fusogenic activity in vitro and decreased haemagglutinating activity, as compared with the wild-type parental strain, phenotype of the virus in cell cultures, embryonated chicken eggs and day-old chickens, overview | Avian orthoavulavirus 1 |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Avian orthoavulavirus 1 | - |
NDV | - |
| Avian orthoavulavirus 1 Anhinga/US(FL)/44083/93 | - |
NDV | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2'-(4-methylumbelliferyl) alpha-D-N-acetylneuraminic acid + H2O | - |
Avian orthoavulavirus 1 | 4-methylumbelliferol + alpha-D-N-acetylneuraminic acid | - |
? |  |
| 2'-(4-methylumbelliferyl) alpha-D-N-acetylneuraminic acid + H2O | - |
Avian orthoavulavirus 1 Anhinga/US(FL)/44083/93 | 4-methylumbelliferol + alpha-D-N-acetylneuraminic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| neuraminidase | - |
Avian orthoavulavirus 1 |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Avian orthoavulavirus 1 |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Avian orthoavulavirus 1 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | attachment of Newcastle disease virus to the host cell is mediated by the haemagglutinin-neuraminidase, a multifunctional protein that has receptor recognition, neuraminidase and fusion promotion activities. Multiple regions of the haemagglutinin-neuraminidase protein globular head are important for fusion promotion, and wild-type levels of neuraminidase activity are not absolutely required for viral infection | Avian orthoavulavirus 1 |
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Release 2023.1 (January 2023)
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