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Literature summary for 3.2.1.18 extracted from

  • Nguyen, P.H.; Nguyen, T.N.; Kang, K.W.; Ndinteh, D.T.; Mbafor, J.T.; Kim, Y.R.; Oh, W.K.
    Prenylated pterocarpans as bacterial neuraminidase inhibitors (2010), Bioorg. Med. Chem., 18, 3335-3344.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
calopocarpin noncompetitive inhibition Clostridium perfringens
calopocarpin noncompetitive inhibition Vibrio cholerae serotype O1
cristacarpin noncompetitive inhibition Clostridium perfringens
cristacarpin noncompetitive inhibition Vibrio cholerae serotype O1
demethylmedicarpin noncompetitive inhibition Clostridium perfringens
demethylmedicarpin noncompetitive inhibition Vibrio cholerae serotype O1
erystagallin A noncompetitive inhibition Clostridium perfringens
erystagallin A noncompetitive inhibition Vibrio cholerae serotype O1
erysubin D competitive inhibitor Clostridium perfringens
erysubin D competitive inhibitor Vibrio cholerae serotype O1
erysubin E noncompetitive inhibition Clostridium perfringens
erysubin E noncompetitive inhibition Vibrio cholerae serotype O1
erythribyssin D i.e. 3-hydroxy-[2',2'-(3'-hydroxy)-dimethylpyrano]-(5',6':10,9)-(6aR,11aR)pterocarpan Clostridium perfringens
erythribyssin D i.e. 3-hydroxy-[2',2'-(3'-hydroxy)-dimethylpyrano]-(5',6':10,9)-(6aR,11aR)pterocarpan Vibrio cholerae serotype O1
erythribyssin L i.e. 9-hydroxy-10-prenyl-[2',2'-(3'-hydroxy)-dimethylpyrano]-(5',6':2,3)-(6aR,11aR)pterocarpan Clostridium perfringens
erythribyssin L i.e. 9-hydroxy-10-prenyl-[2',2'-(3'-hydroxy)-dimethylpyrano]-(5',6':2,3)-(6aR,11aR)pterocarpan Vibrio cholerae serotype O1
erythribyssin M 3-hydroxy-[2',2'-(3'-hydroxy)-dimethylpyrano]-(5',6':10,9)-(6aS,11aS)pterocarpan Clostridium perfringens
erythribyssin M 3-hydroxy-[2',2'-(3'-hydroxy)-dimethylpyrano]-(5',6':10,9)-(6aS,11aS)pterocarpan Vibrio cholerae serotype O1
erythribyssin O noncompetitive inhibition Clostridium perfringens
erythribyssin O noncompetitive inhibition Vibrio cholerae serotype O1
eryvarin D noncompetitive inhibition Clostridium perfringens
eryvarin D noncompetitive inhibition Vibrio cholerae serotype O1
isoneorautenol noncompetitive inhibition Clostridium perfringens
isoneorautenol noncompetitive inhibition Vibrio cholerae serotype O1
neorautenol noncompetitive inhibition Clostridium perfringens
neorautenol noncompetitive inhibition Vibrio cholerae serotype O1
phaseollin competitive inhibitor Clostridium perfringens
phaseollin competitive inhibitor Vibrio cholerae serotype O1
quercetin
-
Clostridium perfringens
quercetin
-
Vibrio cholerae serotype O1
sophorapterocarpan A noncompetitive inhibition Clostridium perfringens
sophorapterocarpan A noncompetitive inhibition Vibrio cholerae serotype O1

Organism

Organism UniProt Comment Textmining
Clostridium perfringens
-
-
-
Vibrio cholerae serotype O1
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl alpha-D-N-acetylneuraminic acid + H2O
-
Clostridium perfringens 4-methylumbelliferone + N-acetylneuraminic acid
-
?
4-methylumbelliferyl alpha-D-N-acetylneuraminic acid + H2O
-
Vibrio cholerae serotype O1 4-methylumbelliferone + N-acetylneuraminic acid
-
?
alpha(2-6)-sialyllactose + H2O
-
Clostridium perfringens sialic acid + lactose
-
?
alpha(2-6)-sialyllactose + H2O
-
Vibrio cholerae serotype O1 sialic acid + lactose
-
?

Synonyms

Synonyms Comment Organism
neuraminidase
-
Clostridium perfringens
neuraminidase
-
Vibrio cholerae serotype O1
sialidase
-
Clostridium perfringens
sialidase
-
Vibrio cholerae serotype O1

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00024
-
erysubin E
-
Clostridium perfringens
0.00031
-
cristacarpin
-
Clostridium perfringens
0.00121
-
erythribyssin O
-
Clostridium perfringens
0.00178
-
sophorapterocarpan A
-
Clostridium perfringens
0.0018
-
erystagallin A
-
Clostridium perfringens
0.00209
-
calopocarpin
-
Clostridium perfringens
0.00255
-
eryvarin D
-
Clostridium perfringens
0.00383
-
demethylmedicarpin
-
Clostridium perfringens
0.00413
-
erythribyssin L
-
Clostridium perfringens
0.00484
-
phaseollin
-
Clostridium perfringens
0.01096
-
isoneorautenol
-
Clostridium perfringens
0.0152
-
erysubin D
-
Clostridium perfringens
0.02174
-
neorautenol
-
Clostridium perfringens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00035
-
-
Vibrio cholerae serotype O1 erythribyssin O
0.0013
-
-
Clostridium perfringens erysubin E
0.00132
-
-
Clostridium perfringens erythribyssin O
0.00157
-
-
Clostridium perfringens calopocarpin
0.00201
-
-
Clostridium perfringens sophorapterocarpan A
0.00204
-
-
Clostridium perfringens erystagallin A
0.00209
-
-
Clostridium perfringens eryvarin D
0.00228
-
-
Clostridium perfringens cristacarpin
0.00279
-
-
Clostridium perfringens erythribyssin L
0.0033
-
-
Vibrio cholerae serotype O1 eryvarin D
0.00639
-
-
Clostridium perfringens demethylmedicarpin
0.00755
-
-
Vibrio cholerae serotype O1 calopocarpin
0.01159
-
-
Vibrio cholerae serotype O1 sophorapterocarpan A
0.01412
-
-
Clostridium perfringens isoneorautenol
0.01948
-
-
Vibrio cholerae serotype O1 erysubin E
0.01982
-
-
Clostridium perfringens neorautenol
0.02203
-
-
Vibrio cholerae serotype O1 cristacarpin
0.02534
-
-
Clostridium perfringens quercetin
0.02639
-
-
Clostridium perfringens erysubin D
0.02639
-
-
Vibrio cholerae serotype O1 erysubin D
0.02714
-
-
Vibrio cholerae serotype O1 erythribyssin L
0.02774
-
-
Vibrio cholerae serotype O1 erystagallin A
0.02954
-
-
Vibrio cholerae serotype O1 demethylmedicarpin
0.0314
-
-
Vibrio cholerae serotype O1 phaseollin
0.03355
-
-
Clostridium perfringens phaseollin
0.0462
-
-
Vibrio cholerae serotype O1 erythribyssin D
0.05311
-
-
Vibrio cholerae serotype O1 neorautenol
0.06475
-
-
Vibrio cholerae serotype O1 isoneorautenol
0.0771
-
-
Clostridium perfringens erythribyssin D
0.07773
-
-
Vibrio cholerae serotype O1 erythribyssin M
0.2054
-
-
Clostridium perfringens erythribyssin M