Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q99519 | - |
- |
Homo sapiens | Q9UQ49 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | only lysosomal Neu1 and plasma membrane-associated Neu3 are detected in freshly isolated and activated human T lymphocytes. Activation of lymphocytes by exposure to anti-CD3 and anti-CD28 IgG results in a ninefold increase in Neu1-specific activity after growth of cells in culture for 5 days. The increase in Neu1 enzyme activity correlates with increased synthesis of Neu1-specific mRNA. Neu1 is present on the surface of freshly isolated and activated CD4 and CD8 T lymphocytes. Cell surface Neu1 is tightly associated with a subunit of protective protein/cathepsin A. Sialidase activity in activated T lymphocytes contributes to the hyposialylation of specific cell surface glycoconjugates and to the production of IFN-gamma | Homo sapiens | - |
T-lymphocyte | only lysosomal Neu1 and plasma membrane-associated Neu3 are detected in freshly isolated and activated human T lymphocytes. Activity of Neu3 changes minimally in activated lymphocytes. Sialidase activity in activated T lymphocytes contributes to the hyposialylation of specific cell surface glycoconjugates and to the production of IFN-gamma | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
NEU1 | - |
Homo sapiens |
Neu3 | - |
Homo sapiens |