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Literature summary for 3.2.1.18 extracted from

  • Agusti, R.; Giorgi, M.E.; Mendoza, V.M.; Gallo-Rodriguez, C.; de Lederkremer, R.M.
    Comparative rates of sialylation by recombinant trans-sialidase and inhibitor properties of synthetic oligosaccharides from Trypanosoma cruzi mucins-containing galactofuranose and galactopyranose (2007), Bioorg. Med. Chem., 15, 2611-2616.
    View publication on PubMed
Search for more literature for 3.2.1.18

Inhibitors

Inhibitors Comment Organism Structure
Galp(beta1,2)Galf(beta1,4)GlcNAc
-
 Trypanosoma cruzi
Galp(beta1,2)Galf(beta1,4)GlcNAcOBn
-
 Trypanosoma cruzi
Galp(beta1,2)Galf(beta1,4)GlcNAcol
-
 Trypanosoma cruzi
Galp(beta1,2)[Galp(beta1,3)]Gal
-
 Trypanosoma cruzi
Galp(beta1,2)[Galp(beta1,3)]GalOBn
-
 Trypanosoma cruzi
Galp(beta1,2)[Galp(beta1,3)]Galol
-
 Trypanosoma cruzi
Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi
Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi
Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi
Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi
Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi
Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi
Galp(beta1,6)GlcNAc
-
 Trypanosoma cruzi
Galp(beta1,6)GlcNAcOBn
-
 Trypanosoma cruzi
Galp(beta1,6)GlcNAcol
-
 Trypanosoma cruzi
Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi
Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 Galp(beta1,6)GlcNAcOBn
-
 Trypanosoma cruzi
0.08
-
 Galp(beta1,6)GlcNAcol
-
 Trypanosoma cruzi
0.08
-
 Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi
0.08
-
 Galp(beta1,2)[Galp(beta1,3)]Gal
-
 Trypanosoma cruzi
0.09
-
 Galp(beta1,2)Galf(beta1,4)GlcNAcol
-
 Trypanosoma cruzi
0.1
-
 Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi
0.15
-
 Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi
0.17
-
 Galp(beta1,6)GlcNAc
-
 Trypanosoma cruzi
0.17
-
 Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi
0.17
-
 Galp(beta1,2)[Galp(beta1,3)]GalOBn
-
 Trypanosoma cruzi
0.18
-
 Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi
0.25
-
 Galp(beta1,2)[Galp(beta1,3)]Galol
-
 Trypanosoma cruzi
0.27
-
 Galp(beta1,2)Galf(beta1,4)GlcNAc
-
 Trypanosoma cruzi
0.31
-
 Galp(beta1,2)Galf(beta1,4)GlcNAcOBn
-
 Trypanosoma cruzi
0.82
-
 Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi
1.07
-
 Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi
2.35
-
 Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-sialyllactose + Galp(beta1,2)Galf(beta1,4)GlcNAc
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,2)Galf(beta1,4)GlcNAcOBn
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,2)Galf(beta1,4)GlcNAcol
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Gal
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]GalOBn
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galol
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi lactose + Neu5Ac(alpha2,3)[Galp(beta1,2)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 ?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi lactose + Neu5Ac(alpha2,3)[Galp(beta1,2)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 ?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi lactose + Neu5Ac(alpha2,3)[Galp(beta1,2)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 ?
3'-sialyllactose + Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,6)GlcNAc
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,6)GlcNAcOBn
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,6)GlcNAcol
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,6)[Galf(beta1,4)]GlcNA
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi ?
-
 ?
3'-sialyllactose + mucin oligosaccharide
-
 Trypanosoma cruzi ?
-
 ?

Synonyms

Synonyms Comment Organism
TcTS
-
 Trypanosoma cruzi
trans-sialidase
-
 Trypanosoma cruzi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.61
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
0.7
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
0.76
-
-
 Trypanosoma cruzi Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAc
0.85
-
-
 Trypanosoma cruzi Galp(beta1,2)Galf(beta1,4)GlcNAcOBn
0.85
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
0.86
-
-
 Trypanosoma cruzi Galp(beta1,6)[Galf(beta1,4)]GlcNAc
0.86
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]Gal
0.93
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]Galol
0.94
-
-
 Trypanosoma cruzi Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
0.98
-
-
 Trypanosoma cruzi Galp(beta1,6)GlcNAcol
1.11
-
-
 Trypanosoma cruzi Galp(beta1,6)GlcNAcOBn
1.13
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]GalOBn
1.14
-
-
 Trypanosoma cruzi Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
1.26
-
-
 Trypanosoma cruzi Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
1.33
-
-
 Trypanosoma cruzi Galp(beta1,6)[Galf(beta1,4)]GlcNAc
1.67
-
-
 Trypanosoma cruzi Galp(beta1,2)Galf(beta1,4)GlcNAcol
2.22
-
-
 Trypanosoma cruzi Galp(beta1,6)GlcNAc
4.43
-
-
 Trypanosoma cruzi Galp(beta1,2)Galf(beta1,4)GlcNAc