Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.166 extracted from

  • Ohmae, M.; Fujita, Y.; Takada, J.; Kimura, S.
    Development of novel inhibitors specific for human heparanase-1 (2013), Chem. Lett., 42, 797-798.
No PubMed abstract available
Search for more literature for 3.2.1.166

Application

Application Comment Organism
medicine specific inhibitors for heparanase are important for suppression of tumor progression and metastasis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
sodium octyl 2-deoxy-2-(sulfonatoamino)-alpha-D-glucopyranoside
-
 Homo sapiens
sodium octyl 4-O-[2-deoxy-2-(sulfoamino)-alpha-D-glucopyranosyl]-beta-D-glucopyranosiduronate specific inhibition Homo sapiens
sodium octyl beta-D-glucopyranosiduronate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted in invasive cells such as inflammatory cells and highly migratory tumor cells Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
inflammatory cell
-
 Homo sapiens
-
additional information the enzyme is secreted in invasive cells such as inflammatory cells and highly migratory tumor cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
heparanase-1
-
 Homo sapiens
Hpa1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4
-
 pH and temperature not specified in the publication Homo sapiens sodium octyl 4-O-[2-deoxy-2-(sulfoamino)-alpha-D-glucopyranosyl]-beta-D-glucopyranosiduronate
6
-
 pH and temperature not specified in the publication Homo sapiens sodium octyl 2-deoxy-2-(sulfonatoamino)-alpha-D-glucopyranoside

General Information

General Information Comment Organism
evolution the enzyme belongs to the glycoside hydrolase family 79, GH79 Homo sapiens
physiological function the enzyme is involved in the process of tumor metastasis Homo sapiens