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Literature summary for 3.2.1.166 extracted from

  • Lerner, I.; Zcharia, E.; Neuman, T.; Hermano, E.; Rubinstein, A.M.; Vlodavsky, I.; Elkin, M.
    Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice (2014), Cell. Mol. Life Sci., 71, 2347-2357.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information generation of Hpa-tg mice in which transgenic heparanase is driven by a constitutive beta-actin promoter in a BALB/c genetic background. The skin of Hpa-tg mice has normal appearance and is characterized by an enhanced hair re-growth, no differences in proliferation of interfollicular keratinocytes between healthy Hpa-tg and wild-type mice. Heparanase overexpression preserves psoriasislike phenotype in mouse skin following multiple 12-O-tetradecanoyl phorbol 12-myristate 13-acetate application Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
8000
-
 1 * 50000 + 1 * 8000, SDS-PAGE Homo sapiens
50000
-
 1 * 50000 + 1 * 8000, SDS-PAGE Homo sapiens
65000
-
 1 * 65000, precursor polypeptide, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Mus musculus BALB/c
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Mus musculus
-
epidermis
-
 Homo sapiens
-
epithelium
-
 Mus musculus
-
epithelium
-
 Homo sapiens
-
macrophage
-
 Mus musculus
-
macrophage
-
 Homo sapiens
-
skin
-
 Mus musculus
-
skin heparanase is preferentially expressed by epidermal keratinocytes in human psoriatic lesions Homo sapiens
-

Subunits

Subunits Comment Organism
heterodimer 1 * 50000 + 1 * 8000, SDS-PAGE Homo sapiens
monomer 1 * 65000, precursor polypeptide, SDS-PAGE Homo sapiens

General Information

General Information Comment Organism
additional information heparanase overexpressing transgenic mice in a model of 12-O-tetradecanoyl phorbol 12-myristate 13-acetate-induced cutaneous inflammation promotes development of mouse skin lesions that strongly recapitulate the human disease in terms of histomorphological appearance and molecularcellular characteristics Mus musculus
physiological function heparanase is the sole mammalian endoglycosidase that cleaves heparan sulfate, the key polysaccharide of the ECM and basement membranes. Heparan sulfate is a ubiquitous macromolecule associated with the cell surface and extracellular matrix of a wide range of tissues and organs. Heparanase is preferentially expressed in human psoriatic lesions. The enzyme has the capacity to promote cancer progression. Enzyme involvement of heparanase in the pathogenesis of psoriasis and a role for the enzyme in facilitating abnormal interactions between immune and epithelial cell subsets of the affected skin Homo sapiens
physiological function the enzyme induces development of psoriasiform skin inflammation in mice. Enzymatic cleavage of heparan sulfate by heparanase profoundly affects a variety of pathophysiological processes, including inflammation, where heparanase activity is often associated with extracellular matrix remodeling, immunocyte activation,and release of chemokines anchored within the extracellular matrix network and cell surface. Heparanase of epidermal origin appears to facilitate abnormal activation of skin-infiltrating macrophages, thus generating psoriasis-like inflammation conditions, characterized by induction of STAT 3, enhanced NF-kappaB signaling, elevated expression of TNF-alpha and increased vascularization. Enzyme involvement of heparanase in the pathogenesis of psoriasis and a role for the enzyme in facilitating abnormal interactions between immune and epithelial cell subsets of the affected skin Mus musculus