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Literature summary for 3.2.1.166 extracted from
- Heparanase is a key player in renal fibrosis by regulating TGF-beta expression and activity (2014), Biochim. Biophys. Acta, 1843, 2122-2128.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | reduced enzyme expression in enzyme-silenced cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| low molecular weight heparin | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelium | - |
Homo sapiens | - |
| HK-2 cell | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| mesenchyme | - |
Homo sapiens | - |
| renal tubule | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HPSE | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | no effect by TGF-beta on the enzyme expression in enzyme-silenced cells | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the lack of heparanase or its inhibition prevents the increased synthesis of TGF-beta by tubular cells in response to pro-fibrotic stimuli such as FGF-2, advanced glycosylation end products and albumin overload. TGF-beta induces an autocrine loop to sustain its signal, whereas the lack of the enzyme partially interferes with this autocrine loop | Homo sapiens |
| physiological function | heparanase is a key player in renal fibrosis by regulating TGF-beta expression and activity, overview. Heparanase is an endo-beta-D-glucuronidase that cleaves heparan-sulfate thus regulating the bioavailability of growth factors (FGF-2, TGF-beta). The enzyme controls FGF-2-induced epithelial-mesenchymal transition in tubular cells and is necessary for the development of diabetic nephropathy in mice. | Homo sapiens |
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Release 2023.1 (January 2023)
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