Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.166 extracted from

  • Fernandes dos Santos, T.C.; Gomes, A.M.; Paschoal, M.E.; Stelling, M.P.; Rumjanek, V.M.; Junior, A.d.o.R.; Valiante, P.M.; Madi, K.; Pereira de Souza, H.S.; Pavao, M.S.; Castelo-Branco, M.T.
    Heparanase expression and localization in different types of human lung cancer (2014), Biochim. Biophys. Acta, 1840, 2599-2608.
    View publication on PubMed
Search for more literature for 3.2.1.166

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell 14 adenocarcinomas, 13 squamous cell carcinomas, 5 large cell carcinomas, and 5 small cell carcinomas. All of the tumor types express heparanase, which is predominantly localized within the cytoplasm and nucleus. Squamous cell carcinomas, large cell carcinomas, and small cell carcinomas have a similar subcellular distribution of heparanase to adenocarcinomas but the distribution is less widespread Homo sapiens
-
lung cancer cell heparanase expression in lung cancer samples to understand lung tumor progression and malignancy, overview. Heparanase expression tends to correlate with tumor node metastasis staging in non-small cell lung carcinoma Homo sapiens
-

General Information

General Information Comment Organism
physiological function heparanase is the only known mammalian glycosidase capable of cleaving heparan sulfate chains. The expression of this enzyme is associated with tumor development because of its ability to degrade extracellular matrix and promote cell invasion Homo sapiens