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Literature summary for 3.2.1.166 extracted from

  • Bitan, M.; Weiss, L.; Reibstein, I.; Zeira, M.; Fellig, Y.; Slavin, S.; Zcharia, E.; Nagler, A.; Vlodavsky, I.
    Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis (2010), Mol. Immunol., 47, 1890-1898.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
8000
-
1 * 50000 + 1 * 8000, SDS-PAGE Mus musculus
50000
-
1 * 50000 + 1 * 8000, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Subunits

Subunits Comment Organism
heterodimer 1 * 50000 + 1 * 8000, SDS-PAGE Mus musculus

General Information

General Information Comment Organism
physiological function heparanase upregulates Th2 cytokines resulting in inhibition of the inflammatory lesion of experimental autoimmune encephalitis. Heparanase inhibits mitogen-induced splenocyte proliferation and mixed lymophocyte reaction through modulation of their repertoire of cytokines indicated by a marked increase in the levels of interleukin-4, interleukin-6 and interleukin-10, and a parallel decrease in interleukin-12 and tissue necrosis factor-alpha Mus musculus