Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
8000 | - |
1 * 50000 + 1 * 8000, SDS-PAGE | Mus musculus |
50000 | - |
1 * 50000 + 1 * 8000, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 50000 + 1 * 8000, SDS-PAGE | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | heparanase upregulates Th2 cytokines resulting in inhibition of the inflammatory lesion of experimental autoimmune encephalitis. Heparanase inhibits mitogen-induced splenocyte proliferation and mixed lymophocyte reaction through modulation of their repertoire of cytokines indicated by a marked increase in the levels of interleukin-4, interleukin-6 and interleukin-10, and a parallel decrease in interleukin-12 and tissue necrosis factor-alpha | Mus musculus |