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Literature summary for 3.2.1.166 extracted from

  • Levy-Adam, F.; Feld, S.; Cohen-Kaplan, V.; Shteingauz, A.; Gross, M.; Arvatz, G.; Naroditsky, I.; Ilan, N.; Doweck, I.; Vlodavsky, I.
    Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity (2010), J. Biol. Chem., 285, 28010-28019.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information the full-length heparanase 2c protein inhibits heparanase enzymatic activity, likely due to its high affinity to heparin and heparan sulfate and its ability to associate physically with heparanase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
x * 50000, active enzyme, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CAL-27 cell
-
Homo sapiens
-
tongue cancer cell
-
Homo sapiens
-
U-87MG cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
extracellular matrix + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 50000, active enzyme, SDS-PAGE Homo sapiens