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Literature summary for 3.2.1.166 extracted from

  • Barash, U.; Cohen-Kaplan, V.; Arvatz, G.; Gingis-Velitski, S.; Levy-Adam, F.; Nativ, O.; Shemesh, R.; Ayalon-Sofer, M.; Ilan, N.; Vlodavsky, I.
    A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics (2010), FASEB J., 24, 1239-1248.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.166

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
15000
-
 x * 15000, heparanase splice variant T5, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CAG cell
-
 Homo sapiens
-
Colo-205 cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
additional information not detected in JAR cells Homo sapiens
-
PANC-1 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
renal cell carcinoma cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 15000, heparanase splice variant T5, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
T5 enzymatically inactive splice variant of human heparanase, in which 144 bp of intron 5 are joined with exon 4 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens heparanase variant T5 expression is up-regulated in 75% of human renal cell carcinoma biopsies up

General Information

General Information Comment Organism
malfunction heparanase variant T5 overexpression results in increased cell proliferation and larger colonies in soft agar, mediated by Src activation Homo sapiens
physiological function heparanase variant T5 activates Src and facilitates cell proliferation and enhances myeloma xenograft development Homo sapiens