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Literature summary for 3.2.1.166 extracted from

  • Cui, H.; Shao, C.; Liu, Q.; Yu, W.; Fang, J.; Yu, W.; Ali, A.; Ding, K.
    Heparanase enhances nerve growth factor induced PC12 cell neuritogenesis via the p38 MAPK pathway (2011), Biochem. J., 440, 273-282.
    View publication on PubMed
Search for more literature for 3.2.1.166

Protein Variants

Protein Variants Comment Organism
Y156A enzymatically inactive proenzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
suramin
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heparan sulfate proteoglycan + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus heparanase expression is induced by nerve growth factor up

General Information

General Information Comment Organism
malfunction heparanase knockdown impairs neurite outgrowth induced by nerve growth factor Rattus norvegicus
physiological function heparanase promotes the nerve growth factor-induced neuritogenesis via MAPK p38 pathway Rattus norvegicus