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Literature summary for 3.2.1.166 extracted from

  • Poon, I.K.; Yee, D.Y.; Jones, A.L.; Wood, R.J.; Davis, D.S.; Freeman, C.; Parish, C.R.; Hulett, M.D.
    Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions (2010), Int. J. Biochem. Cell Biol., 42, 1507-1516.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
histidine-rich glycoprotein GeneBank accession number: BAA21613. Directly interacts with platelet-derived heparanase and enhances its enzymatic activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y251
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
Homo sapiens
-

General Information

General Information Comment Organism
physiological function histidine-rich glycoprotein interferes with heparanase binding to cell surface receptors, particularly heparan sulfate proteoglycans. Thus, the interaction between histidine-rich glycoprotein and heparanase can potentially regulate the role of heparanase in a variety of physiological and pathological conditions Homo sapiens