Protein Variants | Comment | Organism |
---|---|---|
additional information | a splice variant of the Spalax enzyme lacking 16 aa encoded by exon 7. This deletion results in a major defect in trafficking and processing of the heparanase protein, leading to a loss of its enzymatic activity | Nannospalax judaei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Nannospalax galili | - |
- |
- |
Nannospalax judaei | Q333X5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Nannospalax judaei | - |
brain | - |
Nannospalax galili | - |
eye | - |
Nannospalax judaei | - |
heart | - |
Nannospalax judaei | - |
kidney | - |
Nannospalax judaei | - |
kidney | - |
Nannospalax galili | - |
liver | - |
Nannospalax judaei | - |
liver | - |
Nannospalax galili | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heparan sulfate proteoglycan + H2O | heparanase results in release of low-molecular-weight-labeled degradation fragments. The degradation products of heparan sulfate are 5- to 6fold smaller than intact HS side chains | Nannospalax judaei | heparan sulfate fragment + truncated heparan sulfate proteoglycan | - |
? | |
heparan sulfate proteoglycan + H2O | heparanase results in release of low-molecular-weight-labeled degradation fragments. The degradation products of heparan sulfate are 5- to 6fold smaller than intact HS side chains | Nannospalax galili | heparan sulfate fragment + truncated heparan sulfate proteoglycan | - |
? |