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Literature summary for 3.2.1.166 extracted from

  • Schubert, S.Y.; Ilan, N.; Shushy, M.; Ben-Izhak, O.; Vlodavsky, I.; Goldshmidt, O.
    Human heparanase nuclear localization and enzymatic activity (2004), Lab. Invest., 84, 535-544.
    View publication on PubMed
Search for more literature for 3.2.1.166

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus heparanase is translocated into the cell nucleus where it may degrade the nuclear heparan sulfate and thereby affect nuclear functions. 7% of the cytosolic enzyme. Nuclear heparanase colocalizes with nuclear heparan sulfate and is enzymaticaly active Rattus norvegicus 5634
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nucleus heparanase is translocated into the cell nucleus where it may degrade the nuclear heparan sulfate and thereby affect nuclear functions. 7% of the cytosolic enzyme. Nuclear heparanase colocalizes with nuclear heparan sulfate and is enzymaticaly active Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y251
-
-
Rattus norvegicus
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
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 Homo sapiens
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C6 glioma cell
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 Rattus norvegicus
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SMG-C6 cell
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 Rattus norvegicus
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U-87MG cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heparan sulfate proteoglycan + H2O
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 Rattus norvegicus heparan sulfate fragment + truncated heparan sulfate proteoglycan
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 ?
heparan sulfate proteoglycan + H2O
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 Homo sapiens heparan sulfate fragment + truncated heparan sulfate proteoglycan
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 ?