Literature summary for 3.2.1.166 extracted from

Zhao, H.; Liu, H.; Chen, Y.; Xin, X.; Li, J.; Hou, Y.; Zhang, Z.; Zhang, X.; Xie, C.; Geng, M.; Ding, J.
Oligomannurarate sulfate, a novel heparanase inhibitor simultaneously targeting basic fibroblast growth factor, combats tumor angiogenesis and metastasis (2006), Cancer Res., 66, 8779-8787.

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Inhibitors

Inhibitors	Comment	Organism	Structure
oligomannurarate sulfate	the heparanase inhibitor simultaneously targets basic fibroblast growth factor, combats tumor angiogenesis and metastasis. The inhibitor is a promising candidate agent for cancer therapy	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y251	recombinant	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
heparan sulfate proteoglycan + H2O	-	Homo sapiens	heparan sulfate fragment + truncated heparan sulfate proteoglycan	-	?

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Release 2023.1 (January 2023)