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Literature summary for 3.2.1.146 extracted from

  • Repetto, E.; Marino, C.; Uhrig, M.L.; Varela, O.
    Thiodisaccharides with galactofuranose or arabinofuranose as terminal units: synthesis and inhibitory activity of an exo beta-D-galactofuranosidase (2009), Bioorg. Med. Chem., 17, 2703-2711.
    View publication on PubMed
Search for more literature for 3.2.1.146

Inhibitors

Inhibitors Comment Organism Structure
1,2:3,4-di-O-isopropylidene-6-S-(D-galactofuranosyl)-6-thio-alpha-D-galactopyranose pH 4.9, 37°C, 80% enzyme activity at 0.3 mM, beyond that about 75% enzyme activity, 0.2-1.0 mM inhibitor Penicillium fellutanum
2-propyl 3-deoxy-4-S-(beta-D-galactofuranosyl)-4-thio-alpha-D-xylo-hexopyranoside pH 4.9, 37°C, weak inhibitory activity, about 85% enzyme activity at 1 mM, 0.2-1.0 mM inhibitor Penicillium fellutanum
D-galactono-1,4-lactone pH 4.9, 37°C, strong inhibitor, about 40% enzyme activity at 0.1 mM, 10% enzyme activity at 0.2 mM, less than 10% beyond 0.2 mM Penicillium fellutanum
methyl 6-S-(alpha-L-arabinofuranosyl)-6-thio-alpha-D-galactopyranoside pH 4.9, 37°C, 80% enzyme activity at 0.3 mM, beyond that about 75% enzyme activity, 0.2-1.0 mM inhibitor Penicillium fellutanum
methyl 6-S-(beta-D-galactofuranosyl)-6-thio-alpha-D-galactopyranoside pH 4.9, 37°C, 80% enzyme activity at 0.3 mM, beyond that about 65% enzyme activity, 0.2-1.0 mM inhibitor Penicillium fellutanum
methyl 6-S-(beta-D-galactofuranosyl)-6-thio-alpha-D-glucopyranoside pH 4.9, 37°C, weak inhibitory activity, about 85% enzyme activity at 1 mM, 0.2-1.0 mM inhibitor Penicillium fellutanum
additional information no inhibitory activity at 0.2-1.0 mM of methyl 6-S-(alpha-L-arabinofuranosyl)-6-thio-alpha-D-glucopyranoside, pH 4.9, 37°C Penicillium fellutanum

Organism

Organism UniProt Comment Textmining
Penicillium fellutanum
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture medium filtered medium of stationary Penicillium fellutanum culture as source for substrate and enzyme Penicillium fellutanum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl beta-D-galactofuranoside + H2O NaOAc buffer, pH 4.9, 37°C Penicillium fellutanum 4-nitrophenol + D-galactofuranose
-
 ?

Synonyms

Synonyms Comment Organism
beta-D-galactofuranosidase
-
 Penicillium fellutanum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.02
-
 pH 4.9, 37°C, reference inhibitor Penicillium fellutanum D-galactono-1,4-lactone