Literature summary for 3.2.1.143 extracted from

Rotin, L.E.; Gronda, M.; MacLean, N.; Hurren, R.; Wang, X.; Lin, F.H.; Wrana, J.; Datti, A.; Barber, D.L.; Minden, M.D.; Slassi, M.; Schimmer, A.D.
Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism (2016), Oncotarget, 7, 2765-2779 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
ethacridine lactate	PARG inhibitor, synergized with ibrutinib in TEX and OCI-AML2 leukemia cell lines. The combination of ibrutinib and ethacridine induces a synergistic increase in reactive oxygen species that is functionally important to explain the observed cell death, synergistic cytotoxicity of ibrutinib and ethacridine. The ibrutinib-ethacridine combination is preferentially cytotoxic to a subset of primary AML cells compared to normal hematopoietic cells	Homo sapiens
additional information	ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a Bruton's tyrosine kinase (BTK)-independent mechanism, synergistic cytotoxicity of ibrutinib and ethacridine. The ibrutinib-ethacridine combination is preferentially cytotoxic to a subset of primary AML cells compared to normal hematopoietic cells. The inhibitory effect of ibrutinib against BTK, as knockdown of BTK does not sensitize TEX and OCI-AML2 cells to ethacridine treatment	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q86W56	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leukemia cell	-	Homo sapiens	-
additional information	diverse AML cell lines	Homo sapiens	-
OCI-AML2 cell	-	Homo sapiens	-
TEX cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PARG	-	Homo sapiens

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Release 2023.1 (January 2023)