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Literature summary for 3.2.1.143 extracted from
- Role of poly(ADP-ribose) glycohydrolase in the regulation of cell fate in response to benzo(a)pyrene (2012), Exp. Cell Res., 318, 682-690.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | lentiviral gene silencing is used to generate 16HBE cell lines with stably suppressed enzyme, and determination of parameters of cell death and cell cycle following benz[a]pyrene exposure, overview | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q86W56 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 16HBE cell | - |
Homo sapiens | - |
| bronchial epithelial cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PARG | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | benzo(a)pyrene induces the cell cycle in enzyme-suppressed shPARG cells, phenotype, overview | Homo sapiens |
| physiological function | poly(ADP-ribosyl)ation is a crucial regulator of cell fate in response to genotoxic stress, poly(ADP-ribose) degradation is carried out mainly by poly(ADP-ribose) glycohydrolase, role of poly(ADP-ribose) glycohydrolase in the regulation of cell fate in response to benzo(a)pyrene, overview | Homo sapiens |
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