Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a potential target for neuroprotective treatments for retinal degeneration | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | 110 kDa nuclear PARG isoform | Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retina | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
PARG | - |
Mus musculus |
poly-ADP-glycohydrolase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | knockout mutants of isozyme PARG110 show resistance to photoreceptor degeneration, the mutant retina is morphologically and functionally undistinguishable from wild-type. Absence of PARG110 disrupts the poly-ADP-ribose polymerase activation | Mus musculus |
metabolism | isozyme PARG110 and poly-ADP-ribose polymerase-1 act in a positive feedback loop, which is especially active under pathologic conditions | Mus musculus |
physiological function | causal involvement of wild-type isozyme PARG110 in the process of photoreceptor degeneration. Contrasting its anticipated role as a functional antagonist, absence of PARG110 correlated with low PARP activity, suggesting that PARG110 and PARP1 act in a positive feedback loop, which is especially active under pathologic conditions | Mus musculus |