Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.143 extracted from

  • Sahaboglu, A.; Tanimoto, N.; Bolz, S.; Garrido, M.G.; Ueffing, M.; Seeliger, M.W.; Loewenheim, H.; Ekstroem, P.; Paquet-Durand, F.
    Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors (2014), Cell Death Dis., 5, e1234.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the enzyme is a potential target for neuroprotective treatments for retinal degeneration Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus 110 kDa nuclear PARG isoform Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retina
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
PARG
-
Mus musculus
poly-ADP-glycohydrolase
-
Mus musculus

General Information

General Information Comment Organism
malfunction knockout mutants of isozyme PARG110 show resistance to photoreceptor degeneration, the mutant retina is morphologically and functionally undistinguishable from wild-type. Absence of PARG110 disrupts the poly-ADP-ribose polymerase activation Mus musculus
metabolism isozyme PARG110 and poly-ADP-ribose polymerase-1 act in a positive feedback loop, which is especially active under pathologic conditions Mus musculus
physiological function causal involvement of wild-type isozyme PARG110 in the process of photoreceptor degeneration. Contrasting its anticipated role as a functional antagonist, absence of PARG110 correlated with low PARP activity, suggesting that PARG110 and PARP1 act in a positive feedback loop, which is especially active under pathologic conditions Mus musculus