Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine diphosphate (hydroxymethyl) pyrrolidinediol | ADP-HPD | Rattus norvegicus | |
additional information | design and synthesis of phenolic hydrazide hydrazones as potent poly(ADP-ribose) glycohydrolase inhibitors, molecular docking analyses, overview | Rattus norvegicus | |
N'',N'''-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]carbonohydrazide | - |
Rattus norvegicus | |
N'',N'''-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]carbonohydrazide | - |
Rattus norvegicus | |
N'1,N'3-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]propanedihydrazide | - |
Rattus norvegicus | |
N'1,N'3-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]propanedihydrazide | - |
Rattus norvegicus | |
N'1,N'4-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]butanedihydrazide | - |
Rattus norvegicus | |
N'1,N'4-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]butanedihydrazide | - |
Rattus norvegicus | |
N'1,N'4-bis[(E)-(3,4-dihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide | slight inhibition | Rattus norvegicus | |
N'1,N'5-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]pentanedihydrazide | - |
Rattus norvegicus | |
N'1,N'5-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]pentanedihydrazide | - |
Rattus norvegicus | |
N'1-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-N'3-[(Z)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | - |
Rattus norvegicus | |
N'1-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-N'4-[(Z)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide | - |
Rattus norvegicus | |
N'1-[(E)-(2,3-dihydroxyphenyl)methylidene]-N'3-[(Z)-(2,3-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | - |
Rattus norvegicus | |
N'1-[(E)-(2,4,6-trihydroxyphenyl)methylidene]-N'3-[(Z)-(2,4,6-trihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | - |
Rattus norvegicus | |
N'1-[(E)-(2,4,6-trihydroxyphenyl)methylidene]-N'4-[(Z)-(2,4,6-trihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide | - |
Rattus norvegicus | |
N'1-[(E)-(2,4-dihydroxyphenyl)methylidene]-N'3-[(Z)-(2,4-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | - |
Rattus norvegicus | |
N'1-[(E)-(3,4,5-trihydroxyphenyl)methylidene]-N'3-[(Z)-(3,4,5-trihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | - |
Rattus norvegicus | |
N'1-[(E)-(3,4,5-trihydroxyphenyl)methylidene]-N'4-[(Z)-(3,4,5-trihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide | - |
Rattus norvegicus | |
N'1-[(E)-(3,4-dihydroxyphenyl)methylidene]-N'3-[(Z)-(3,4-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | - |
Rattus norvegicus | |
N'1-[(E)-(4,6-dihydroxycyclohexa-1,3-dien-1-yl)methylidene]-N'4-[(E)-(2,4-dihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide | slight inhibition | Rattus norvegicus | |
N'1-[(E)-(5,6-dihydroxycyclohexa-1,3-dien-1-yl)methylidene]-N'4-[(E)-(2,3-dihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide | slight inhibition | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
PARG | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0001 | - |
pH 7.5, 37°C | Rattus norvegicus | adenosine diphosphate (hydroxymethyl) pyrrolidinediol | |
0.001 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-N'4-[(Z)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide | |
0.0016 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1,N'3-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]propanedihydrazide | |
0.0021 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1-[(E)-(3,4,5-trihydroxyphenyl)methylidene]-N'4-[(Z)-(3,4,5-trihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide | |
0.0028 | - |
pH 7.5, 37°C | Rattus norvegicus | N'',N'''-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]carbonohydrazide | |
0.0031 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-N'3-[(Z)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | |
0.0031 | - |
pH 7.5, 37°C | Rattus norvegicus | N'',N'''-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]carbonohydrazide | |
0.0032 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1-[(E)-(3,4,5-trihydroxyphenyl)methylidene]-N'3-[(Z)-(3,4,5-trihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | |
0.0082 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1,N'4-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]butanedihydrazide | |
0.0098 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1,N'4-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]butanedihydrazide | |
0.0099 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1-[(E)-(2,4,6-trihydroxyphenyl)methylidene]-N'4-[(Z)-(2,4,6-trihydroxyphenyl)methylidene]benzene-1,4-dicarbohydrazide | |
0.0139 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1,N'5-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]pentanedihydrazide | |
0.0148 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1-[(E)-(2,3-dihydroxyphenyl)methylidene]-N'3-[(Z)-(2,3-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | |
0.0154 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1,N'3-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]propanedihydrazide | |
0.0188 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1-[(E)-(2,4,6-trihydroxyphenyl)methylidene]-N'3-[(Z)-(2,4,6-trihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | |
0.0192 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1-[(E)-(3,4-dihydroxyphenyl)methylidene]-N'3-[(Z)-(3,4-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | |
0.0274 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1,N'5-bis[(E)-(3,4,5-trihydroxyphenyl)methylidene]pentanedihydrazide | |
0.0401 | - |
pH 7.5, 37°C | Rattus norvegicus | N'1-[(E)-(2,4-dihydroxyphenyl)methylidene]-N'3-[(Z)-(2,4-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide |
General Information | Comment | Organism |
---|---|---|
malfunction | genetic disruption of the enzyme leads to increased level of cell death by accumulation of poly(ADP-ribose) | Rattus norvegicus |
additional information | the Glu752 residue plays an important role in the enzyme's catalytic activity by functioning as a general acid or base to protonate the 2'-OH of the ribose of the leaving group, and subsequently activating a water molecule for nucleophilic attack | Rattus norvegicus |
physiological function | the enzyme is responsible for the degradation of poly(ADP-ribose) (PAR) polymers | Rattus norvegicus |