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Literature summary for 3.2.1.143 extracted from
- Role of poly(ADP-ribose) glycohydrolase silencing in DNA hypomethylation induced by benzo(a)pyrene (2014), Biochem. Biophys. Res. Commun., 452, 708-714.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | inhibitors of the enzyme are potent anticancer drug candidates | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | constitutive expression shRNA directed against the catalytic domain of all enzyme isoforms in the 16HBE cell line | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| poly(ADP-D-ribose)n + H2O | Homo sapiens | - |
poly(ADP-D-ribose)n-1 + ADP-ribose | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 16HBE cell | - |
Homo sapiens | - |
| bronchial epithelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| poly(ADP-D-ribose)n + H2O | - |
Homo sapiens | poly(ADP-D-ribose)n-1 + ADP-ribose | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PARG | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | molecular mechanism(s) connecting poly(ADP-ribosyl)ation with DNA methylation, giving a possible explanation as to how DNA methylation modulates by poly(ADP-ribosyl)ation as the posttranslational modification. DNA methyltransferases also interact with poly(ADP-D-ribose) | Homo sapiens |
| physiological function | by regulating the hydrolytic arm of poly(ADP-ribosyl)ation, the enzyme participates in a number of biological processes, including the repair of DNA damage, chromatin dynamics, transcriptional regulation, and cell death. Role of silencing of the enzyme in DNA methylation pattern changed by benzo(a)pyrene, a carcinogen cytotoxic which can trigger extensive cellular responses | Homo sapiens |
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