Literature summary for 3.2.1.143 extracted from

Whatcott, C.J.; Meyer-Ficca, M.L.; Meyer, R.G.; Jacobson, M.K.
A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence (2009), Exp. Cell Res., 315, 3477-3485.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression of isoform PARG59 in HeLa cell	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	transient transfection of HeLa cells with PARG expression constructs with amino acids encoded by exon 4 at the N-terminus. Proteins are targeted to the mitochondria. Deletion and missense mutants allow identification of a canonical N-terminal mitochondrial targeting sequence consisting of the first 16 amino acids encoded by PARG exon 4. Sub-mitochondrial localization experiments indicate that this mitochondrial PARG isoform is targeted to the mitochondrial matrix	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	PARG59 expression constructs with amino acids encoded by exon 4 at the N-terminus are targeted to the mitochondrial matrix	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform PARG59	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	PARG59 expression constructs with amino acids encoded by exon 4 at the N-terminus are targeted to the mitochondria. Deletion and missense mutants allow identification of a canonical N-terminal mitochondrial targeting sequence consisting of the first 16 amino acids encoded by PARG exon 4. Sub-mitochondrial localization experiments indicate that this mitochondrial PARG isoform is targeted to the mitochondrial matrix	Homo sapiens

Synonyms

Synonyms	Comment	Organism
PARG59	-	Homo sapiens

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Release 2023.1 (January 2023)