Literature summary for 3.2.1.143 extracted from

Cortes, U.; Tong, W.M.; Coyle, D.L.; Meyer-Ficca, M.L.; Meyer, R.G.; Petrilli, V.; Herceg, Z.; Jacobson, E.L.; Jacobson, M.K.; Wang, Z.Q.
Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice (2004), Mol. Cell. Biol., 24, 7163-7178.

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Protein Variants

Protein Variants	Comment	Organism
additional information	deletion of enzyme gene by gene targeting in embryonic stem cells and mice, severe compromisation of automodification of poly(ADP-ribose) polymerase 1. Enzyme deficient mice are viable and fertile, but hypersensitive to alkylating agents and ionizing radiation, and susceptible to streptozotocin-induced diabetes and endotoxic shock	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryonic stem cell	embryonic stem cell	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
PARG110	-	Mus musculus

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Release 2023.1 (January 2023)