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Literature summary for 3.2.1.143 extracted from

  • Oka, S.; Kato, J.; Moss, J.
    Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase (2006), J. Biol. Chem., 281, 705-713.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol activation Homo sapiens

Protein Variants

Protein Variants Comment Organism
D77N/D78N no enzymic activity, binding of ADP-ribose is similar to wild-type Mus musculus
E238Q/E239Q catalytic activity similar to wild-type Mus musculus
E261Q/E262Q catalytic activity similar to wild-type Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-
nucleus
-
Mus musculus 5634
-
nucleus
-
Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
MgCl2 10 mM, activation Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39000
-
x * 39000, SDS-PAGE Mus musculus
39000
-
x * 39000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NX46
-
-
Mus musculus Q8CG72
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain high abundance Mus musculus
-
liver high abundance Mus musculus
-
additional information present in all tissues tested Mus musculus
-
ovary high abundance Mus musculus
-
spleen high abundance Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no substrate: mono-ADP-ribosylated proteins, ADP-ribose-arginine, ADP-ribose-cysteine, ADP-ribose-diphthaminde, ADP-ribose-asparagine Mus musculus ?
-
?
poly(ADP-ribose)n + H2O
-
Mus musculus ADP-ribose and lower molecular weight poly(ADP-ribose)n fragment products, no product: phosphoribosyl-AMP ?
poly(ADP-ribose)n + H2O
-
Homo sapiens ADP-ribose and lower molecular weight poly(ADP-ribose)n fragment products, no product: phosphoribosyl-AMP ?
poly(ADP-ribose)n-poly(ADP-ribose) polymerase + H2O
-
Homo sapiens ADP-ribose + poly(ADP-ribose) polymerase
-
?

Subunits

Subunits Comment Organism
? x * 39000, SDS-PAGE Mus musculus
? x * 39000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ARH3
-
Mus musculus
ARH3
-
Homo sapiens