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Literature summary for 3.2.1.143 extracted from

  • Uchiumi, F.; Ikeda, D.; Tanuma, S.
    Changes in the activities and gene expressions of poly(ADP-ribose) glycohydrolases during the differentiation of human promyelocytic leukemia cell line HL-60 (2004), Biochim. Biophys. Acta, 1676, 1-11.
    View publication on PubMed
Search for more literature for 3.2.1.143

Inhibitors

Inhibitors Comment Organism Structure
12-O-tetradecanoyl-phorbol-13-acetate reduction of nuclear enzyme activity to 30-40% of control, cytosolic activity remains unchanged. Reduction is suppressed by protein kinase C inhibitor H7. Enzyme expression is reduced in presence of 12-O-tetradecanoyl-phorbol-13-acetate Homo sapiens
Tannic acid continous decrease in activity of nuclear enzyme activity, reduction in enzyme expression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
nucleus reduction of nuclear enzyme activity to 30-40% of control by treatment with 12-O-tetradecanoyl-phorbol-13-acetate, cytosolic activity remains unchanged. Reduction is suppressed by protein kinase C inhibitor H7 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens transient decrease in nuclear enzyme activity is important for the onset of differentiation of HL-60 cells to macrophage-like cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86W56
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell promyelocytic leukemia cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information transient decrease in nuclear enzyme activity is important for the onset of differentiation of HL-60 cells to macrophage-like cells Homo sapiens ?
-
 ?