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Literature summary for 3.2.1.14 extracted from

  • Baker, L.G.; Specht, C.A.; Lodge, J.K.
    Chitinases are essential for sexual development but not vegetative growth in Cryptococcus neoformans (2009), Eukaryot. Cell, 8, 1692-1705.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information a mutant strain lacking isoforms chi2, chi21, chi22, chi4 is unable to cleave 4-methylumbelliferyl-(GlcNAc)3. Strains containing only Chi4 or Chi21 also show no activity on 4-methylumbelliferyl-(GlcNAc)3. A strain containing only the endochitinase Chi22 has measurable activity against 4-methylumbelliferyl-(GlcNAc)3 when the cells are grown on either GlcNAc or glucose as a carbon source, although less on the glucose carbon source. A strain containing only Chi2 has measurable activity when grown on both glucose and GlcNAc Cryptococcus neoformans

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular isoform Chi22 Cryptococcus neoformans
-
-

Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans
-
-
-

Synonyms

Synonyms Comment Organism
Chi21
-
 Cryptococcus neoformans
Chi22
-
 Cryptococcus neoformans

General Information

General Information Comment Organism
physiological function endochitinases Chi2, Chi22 actively degrade chitinoligomeric substrates. A mutant strain lacking isoforms chi2, chi21, chi22, chi4 is unable to cleave 4-methylumbelliferyl-(GlcNAc)3. Strains containing only Chi4 or Chi21 also show no activity on 4-methylumbelliferyl-(GlcNAc)3. A strain containing only the endochitinase Chi22 has measurable activity against 4-methylumbelliferyl-(GlcNAc)3 when the cells are grown on either GlcNAc or glucose as a carbon source, although less on the glucose carbon source. A strain containing only Chi2 has measurable activity when grown on both glucose and GlcNAc Chi2, Chi21, and Chi4 are each involved in sexual reproduction Cryptococcus neoformans