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Literature summary for 3.2.1.114 extracted from

  • Suzuki, K.; Yamada, T.; Yamazaki, K.; Hirota, M.; Ishihara, N.; Sakamoto, M.; Takahashi, D.; Iijima, H.; Hase, K.
    Intestinal epithelial cell-specific deletion of alpha-mannosidase II ameliorates experimental colitis (2018), Cell Struct. Funct., 43, 25-39 .
    View publication on PubMed
Search for more literature for 3.2.1.114

Application

Application Comment Organism
medicine single nucleotide polymorphisms in MAN2A1 may be a genetic factor for inflammatory bowel disease Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P27046
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Source Tissue

Source Tissue Comment Organism Textmining
intestinal epithelium cells selectively express alpha-mannosidase II, with minimal expression of its isozyme, alpha-mannosidase IIx Mus musculus
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intestine epithelium Mus musculus
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Synonyms

Synonyms Comment Organism
alpha-mannosidase II
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 Mus musculus
alpha-MII
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 Mus musculus
MAN2A1
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 Mus musculus

General Information

General Information Comment Organism
malfunction alpha-mannosidase II deficiency has a minimal effect on N-glycan maturation in most cell types due to the compensation by alpha-mannosidase IIx, ablation of alpha-MII impairs the maturation of N-glycans in intestinal epithelial cells. alpha-mannosidase II (DELTA intestinal epithelial cell) mice are less susceptible to dextran sulfate sodium-induced colitis compared with control littermates. Neutrophil infiltration in the colonic mucosa is attenuated in alpha-mannosidase II (DELTA intestinal epithelial cell) mice. Gene expression levels of neutrophil-attracting chemokines are downregulated in the colonic tissue Mus musculus
physiological function the enzyme plays a crucial, but not exclusive, role in the maturation of N-glycans. Intestinal epithelial cell alpha-mannosidase II promotes intestinal inflammation by facilitating chemokine expression Mus musculus