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Literature summary for 3.2.1.114 extracted from

  • Kuntz, D.A.; Tarling, C.A.; Withers, S.G.; Rose, D.R.
    Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen (2008), Biochemistry, 47, 10058-10068.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Drosophila melanogaster
in complex with inhibitors mannoimidazole, glucoimidazole, N-octyl-6-epi-valienamine, gluco-hydroxyiminolactam, and [[(3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)piperidin-2-ylidene]amino] N-(4-chlorophenyl)carbamate Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
(3S,4S,5R,6R,E)-3,4,5-trihydroxy-6-(hydroxymethyl)piperidin-2-one O-4-chlorophenylcarbamoyl oxime
-
Drosophila melanogaster
deoxymannojirimycin
-
Drosophila melanogaster
gluco-hydroxyiminolactam
-
Drosophila melanogaster
glucoimidazole
-
Drosophila melanogaster
kifunensine
-
Drosophila melanogaster
mannoimidazole
-
Drosophila melanogaster
N-octyl-6-epi-valienamine
-
Drosophila melanogaster
noeuromycin
-
Drosophila melanogaster
swainsonine
-
Drosophila melanogaster
[[(3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)piperidin-2-ylidene]amino] N-(4-chlorophenyl)carbamate
-
Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
Drosophila melanogaster 5794
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q24451 isoform GMII
-
Drosophila melanogaster Q24451
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SCHNEIDER-2 cell
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,5-dinitrophenyl-alpha-D-mannopyranoside + H2O
-
Drosophila melanogaster 2,5-dinitrophenol + D-mannose
-
?
2,5-dinitrophenyl-alpha-D-mannopyranoside + H2O pH 5.6, room temperature Drosophila melanogaster 2,5-dinitrophenol + alpha-D-mannose
-
?

Synonyms

Synonyms Comment Organism
alpha-mannosidase
-
Drosophila melanogaster
dGMII
-
Drosophila melanogaster
Drosophila GMII
-
Drosophila melanogaster
glycoside hydrolase
-
Drosophila melanogaster
Golgi alpha-mannosidase II
-
Drosophila melanogaster

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00002
-
swainsonine
-
Drosophila melanogaster
0.00002
-
swainsonine pH 5.6 Drosophila melanogaster
0.002
-
mannoimidazole
-
Drosophila melanogaster
0.002
-
mannoimidazole pH 5.6 Drosophila melanogaster
0.013
-
glucoimidazole
-
Drosophila melanogaster
0.013
-
glucoimidazole pH 5.6 Drosophila melanogaster
0.017
-
N-octyl-6-epi-valienamine
-
Drosophila melanogaster
0.017
-
N-octyl-6-epi-valienamine pH 5.6 Drosophila melanogaster
0.02
-
noeuromycin
-
Drosophila melanogaster
0.02
-
noeuromycin pH 5.6 Drosophila melanogaster
0.07
-
gluco-hydroxyiminolactam
-
Drosophila melanogaster
0.07
-
gluco-hydroxyiminolactam pH 5.6 Drosophila melanogaster
0.4
-
1-deoxymannojirimycin
-
Drosophila melanogaster
0.4
-
deoxymannojirimycin pH 5.6 Drosophila melanogaster
0.52
-
(3S,4S,5R,6R,E)-3,4,5-trihydroxy-6-(hydroxymethyl)piperidin-2-one O-4-chlorophenylcarbamoyl oxime
-
Drosophila melanogaster
0.52
-
[[(3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)piperidin-2-ylidene]amino] N-(4-chlorophenyl)carbamate pH 5.6 Drosophila melanogaster
5
-
kifunensine pH 5.6 Drosophila melanogaster