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Literature summary for 3.2.1.114 extracted from

  • Igdoura, S.A.; Herscovics, A.; Lal, A.; Moremen, K.W.; Morales, C.R.; Hermo, L.
    alpha-Mannosidases involved in N-glycan processing show cell specificity and distinct subcompartmentalization within the Golgi apparatus of cells in the testis and epididymis (1999), Eur. J. Cell Biol., 78, 441-452.
    View publication on PubMed
Search for more literature for 3.2.1.114

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi membrane type II transmembrane enzyme, subcompartmental localization, mainly over medial saccules of the Golgi stack Rattus norvegicus 139
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O Rattus norvegicus involved in N-glycan maturation, acts after GlcNAc transferase I to remove 2 mannose residues to form GlcNAc(Man)3(GlcNAc)2 prior to extension into complex N-glycans Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 alpha-D-mannose
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male sprague-dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
epididymis clear cells in all epdididymal regions, not in principal cells Rattus norvegicus
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Leydig cell in the Golgi apparatus Rattus norvegicus
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Sertoli cell in the Golgi apparatus Rattus norvegicus
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testis in the Golgi apparatus of Sertoli and Leydig cells Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O acts after GlcNAc transferase I to remove the alpha-1,3- and alpha-1,6-linked mannose residue Rattus norvegicus Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 alpha-D-mannose
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Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O involved in N-glycan maturation, acts after GlcNAc transferase I to remove 2 mannose residues to form GlcNAc(Man)3(GlcNAc)2 prior to extension into complex N-glycans Rattus norvegicus Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 alpha-D-mannose
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