Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | - |
Homo sapiens | 5794 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P33908 | - |
- |
Homo sapiens | Q9NR34 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
MAN1A1 | - |
Homo sapiens |
MAN1C1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | aberrant regulation of alpha-1,2 mannosidases can result in cancer. MAN1C1 plays a role in tumor suppression in hepatocarcinogenesis. Down-regulation of MAN1C activates unfolded protein response during hepatocarcinogenesis | Homo sapiens |
malfunction | aberrant regulation of alpha-1,2 mannosidases can result in cancer. Upregulation of MAN1A1 activates unfolded protein response during hepatocarcinogenesis | Homo sapiens |
physiological function | key enzyme in N-glycosylation is required for the formation of mature glycoproteins in eukaryotes. MAN1A1 represents an oncogene. Upregulation of MAN1A1 activates unfolded protein response during hepatocarcinogenesis | Homo sapiens |
physiological function | key enzymes in N-glycosylation is required for the formation of mature glycoproteins in eukaryotes. MAN1C1 plays a role in tumor suppression in hepatocarcinogenesis. Down-regulation of MAN1C activates unfolded protein response during hepatocarcinogenesis | Homo sapiens |