BRENDA - Enzyme Database
show all sequences of 3.2.1.113

Effect of phospholipids on alpha-1,2-mannosidase activity

Forsee, W.T.; Springfield, J.D.; Schutzbach, J.S.; J. Biol. Chem. 257, 9963-9967 (1982)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
no activation by negatively charged phospholipids, dibutyryl-phosphocholine
Oryctolagus cuniculus
phosphatidylcholine
activation, with acyl-chains of different lengths, above C-4
Oryctolagus cuniculus
phosphatidylethanolamine
activation, in the presence of 3.5 mM Triton X-100
Oryctolagus cuniculus
Triton X-100
activation together with zwitterionic phospholipids
Oryctolagus cuniculus
Zwitterionic phospholipids
activation, required for solubilized and purified enzyme, independent of acyl chain length or degree of saturation, an ordered lipid structure of either micelles or bilayers, mixed micelles together with Triton X-100
Oryctolagus cuniculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Oryctolagus cuniculus
16020
-
microsome
-
Oryctolagus cuniculus
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Oryctolagus cuniculus
-
-
-
Purification (Commentary)
Commentary
Organism
partial, solubilization requires non-ionic detergents
Oryctolagus cuniculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O
i.e. Manalpha(1-2)Manalpha(1-2)Manalpha(1-3) (Manalpha(1-6))ManbetaGlcNAc-betaGlcNAc
646572
Oryctolagus cuniculus
(Man)4(GlcNAc)2 + (Man)3(GlcNAc)2 + D-mannose
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Oryctolagus cuniculus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
6.5
in the presence of egg yolk lyso-phosphatidylcholine
Oryctolagus cuniculus
6.5
-
in the presence of soybean phosphatidylinositol
Oryctolagus cuniculus
pH Range
pH Minimum
pH Maximum
Commentary
Organism
5.2
7.3
about half-maximal activity at pH 5.2 and 7.3, in the presence of egg yolk lyso-phosphatidylcholine
Oryctolagus cuniculus
5.5
7.5
about half-maximal activity at pH 5.5 and 7.5, in the presence of soybean phosphatidylinositol
Oryctolagus cuniculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
no activation by negatively charged phospholipids, dibutyryl-phosphocholine
Oryctolagus cuniculus
phosphatidylcholine
activation, with acyl-chains of different lengths, above C-4
Oryctolagus cuniculus
phosphatidylethanolamine
activation, in the presence of 3.5 mM Triton X-100
Oryctolagus cuniculus
Triton X-100
activation together with zwitterionic phospholipids
Oryctolagus cuniculus
Zwitterionic phospholipids
activation, required for solubilized and purified enzyme, independent of acyl chain length or degree of saturation, an ordered lipid structure of either micelles or bilayers, mixed micelles together with Triton X-100
Oryctolagus cuniculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Oryctolagus cuniculus
16020
-
microsome
-
Oryctolagus cuniculus
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
partial, solubilization requires non-ionic detergents
Oryctolagus cuniculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O
i.e. Manalpha(1-2)Manalpha(1-2)Manalpha(1-3) (Manalpha(1-6))ManbetaGlcNAc-betaGlcNAc
646572
Oryctolagus cuniculus
(Man)4(GlcNAc)2 + (Man)3(GlcNAc)2 + D-mannose
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Oryctolagus cuniculus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
6.5
in the presence of egg yolk lyso-phosphatidylcholine
Oryctolagus cuniculus
6.5
-
in the presence of soybean phosphatidylinositol
Oryctolagus cuniculus
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
5.2
7.3
about half-maximal activity at pH 5.2 and 7.3, in the presence of egg yolk lyso-phosphatidylcholine
Oryctolagus cuniculus
5.5
7.5
about half-maximal activity at pH 5.5 and 7.5, in the presence of soybean phosphatidylinositol
Oryctolagus cuniculus
Other publictions for EC 3.2.1.113
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
751118
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1
3
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751168
Li
alpha-1,2-Mannosidase MAN1C1 ...
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J. Cancer
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4618-4626
2018
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1
1
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1
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1
1
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751608
Liu
Trimming of N-glycans by the ...
Arabidopsis thaliana
Mol. Plant
11
678-690
2018
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-
-
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1
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2
4
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750718
Tu
Up-regulation of Golgi alpha- ...
Homo sapiens
Hepatol. Commun.
1
230-247
2017
-
-
-
-
-
-
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1
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2
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2
4
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752329
Hu
Hepatitis B virus upregulates ...
Homo sapiens
World J. Gastroenterol.
22
9534-9543
2016
-
1
-
-
1
-
-
-
-
-
-
-
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7
-
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-
-
6
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4
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4
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24
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
715684
Isoyama-Tanaka
Improved expression and charac ...
Homo sapiens
J. Biosci. Bioeng.
112
14-19
2011
-
-
1
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-
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4
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3
1
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2
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1
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1
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8
1
2
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2
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2
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2
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2
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6
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5
2
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2
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2
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8
2
2
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2
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2
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2
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-
703909
Kajiura
Two Arabidopsis thaliana Golgi ...
Arabidopsis thaliana
Glycobiology
20
235-247
2010
-
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1
-
-
-
3
-
1
2
1
-
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7
-
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1
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4
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1
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1
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2
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1
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4
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1
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1
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2
-
2
-
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1
1
-
-
-
706455
Long
Alpha-1,2-mannosidase and henc ...
Mus musculus
PLoS ONE
5
e8894
2010
-
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-
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2
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1
2
2
1
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695429
Liu
Reduced Expression of Alpha-1, ...
Caenorhabditis elegans, Caenorhabditis elegans N2 Bristol, Drosophila melanogaster
Aging Cell
8
370-379
2009
-
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4
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5
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9
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703328
Zhou
Functional analysis of an alph ...
Magnaporthe oryzae, Magnaporthe oryzae Guy11
Curr. Genet.
55
485-496
2009
-
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3
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7
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1
1
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4
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703935
Pan
Single nucleotide polymorphism ...
Homo sapiens
Hepatology
50
275-281
2009
-
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1
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704576
Chen
T cell receptor signaling co-r ...
Homo sapiens
J. Biol. Chem.
284
32454-32461
2009
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1
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1
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704777
Clerc
Htm1 protein generates the N-g ...
Saccharomyces cerevisiae
J. Cell Biol.
184
159-172
2009
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3
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1
1
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751841
Liebminger
Class I alpha-mannosidases ar ...
Arabidopsis thaliana
Plant Cell
21
3850-3867
2009
-
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1
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4
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1
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2
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4
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8
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4
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1
2
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677330
Lobsanov
Modulation of activity by Arg4 ...
Penicillium citrinum
Acta Crystallogr. Sect. D
64
227-236
2008
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1
1
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2
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2
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677614
Mora-Montes
Conversion of alpha1,2-mannosi ...
Candida albicans
Antonie van Leeuwenhoek
93
61-69
2008
-
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2
1
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677573
Lunetta
Molecular cloning and expressi ...
Coccidioides posadasii
Ann. N. Y. Acad. Sci.
1111
164-180
2007
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1
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1
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677980
Hosokawa
Stimulation of ERAD of misfold ...
Homo sapiens, Mus musculus
Biochem. Biophys. Res. Commun.
362
626-632
2007
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2
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2
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3
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6
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4
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21
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3
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3
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6
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21
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680806
Tremblay
Respiratory distress and neona ...
Mus musculus
J. Biol. Chem.
282
2558-2566
2007
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1
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1
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7
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1
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13
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1
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3
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3
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22
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680869
Wu
Human endoplasmic reticulum ma ...
Homo sapiens, Mus musculus
J. Biol. Chem.
282
4841-4849
2007
-
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1
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11
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3
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1
1
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4
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1
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1
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1
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11
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3
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1
1
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1
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1
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664385
Akao
Cloning and expression of 1,2- ...
Aspergillus oryzae
Biosci. Biotechnol. Biochem.
70
471-479
2006
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1
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3
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2
2
1
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3
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1
1
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1
1
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3
1
1
1
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1
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1
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3
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2
2
1
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1
1
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1
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677921
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1-Deoxymannojirimycin, the alp ...
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682320
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Plant N-glycan processing enzy ...
Arabidopsis thaliana, Glycine max, Nicotiana tabacum, Solanum lycopersicum
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Tatara
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Mechanism of class 1 (glycosyl ...
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Comparison of kifunensine and ...
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Structure of Penicillium citri ...
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Lipari
Calcium Binding to the Class I ...
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1
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646583
Schweden
Characterization of trimming M ...
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5
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7
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1
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1
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5
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3
2
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1
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2
1
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7
1
1
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1
1
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Forsee
Purification and characterizat ...
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1
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2
1
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4
1
1
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1
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1
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10
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1
4
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1
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2
1
1
4
1
1
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1
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1
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646585
Tulsiani
Mannosidase IA from rat liver ...
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7
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6
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7
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1
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1
1
1
6
1
1
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1
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646581
Kobata
alpha-Mannosidases I and II fr ...
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1987
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1
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4
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1
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1
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2
1
2
4
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1
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1
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135991
Shigematsu
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Molecular and enzymic properti ...
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1986
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12
1
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2
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1
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1
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2
1
1
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12
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1
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1
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1
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2
1
1
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135992
Szumilo
Purification and properties of ...
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7
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6
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1
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3
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7
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6
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1
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1
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1
1
1
3
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1
1
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646577
Tanimoto
Improved purification of Asper ...
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1
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1
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646579
Schweden
Purification and characterizat ...
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6
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1
1
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6
1
1
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1
1
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6
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3
1
1
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1
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1
1
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6
1
1
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1
1
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646575
Forsee
Characterization of microsomal ...
Vigna radiata var. radiata
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7
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1
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2
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2
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1
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1
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7
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3
1
2
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1
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2
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2
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1
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1
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646576
Palamarczyk
1,4-Dideoxy-1,4-imino-D-mannit ...
Rattus norvegicus
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2
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646574
Chandrasekaran
Purification and properties of ...
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2
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5
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135998
Tulsiani
alpha-D-Mannosidases of rat li ...
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3660-3668
1982
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1
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1
1
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13
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1
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3
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1
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1
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1
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2
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1
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1
1
1
13
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1
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3
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1
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136000
Yamamoto
Purification and characterizat ...
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1971-1979
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5
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1
1
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15
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1
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1
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1
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1
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1
5
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1
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1
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1
1
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646572
Forsee
Effect of phospholipids on alp ...
Oryctolagus cuniculus
J. Biol. Chem.
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9963-9967
1982
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2
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5
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2
2
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646570
Tabas
Purification and characterizat ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
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11655-11663
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12
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1
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1
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1
1
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4
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1
2
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2
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1
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1
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1
12
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1
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1
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1
1
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