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Literature summary for 3.2.1.106 extracted from

  • Rawlings, A.; Lomas, H.; Pilling, A.; Lee, M.; Alonzi, D.; Rountree, J.; Jenkinson, S.; Fleet, G.; Dwek, R.; Jones, J.; Butters, T.
    Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin glucosidase inhibitors (2009), ChemBioChem, 10, 1101-1105.
    View publication on PubMed
Search for more literature for 3.2.1.106

Inhibitors

Inhibitors Comment Organism Structure
N-(6'-(2'',4''-dinitrophenylamino)hexyl)-1-deoxynojirimycin
-
 Rattus norvegicus
N-(6'-(4''-azido-2''-nitrophenylamino)hexyl)-1-deoxynojirimycin highly potent inhibitor of alpha-glucosidase I Rattus norvegicus
N-butyl-deoxynojirimycin
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Rattus norvegicus 5783
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Glc3Man5GlcNAc + H2O
-
 Rattus norvegicus D-glucose + Glc2Man5GlcNAc
-
 ?

Synonyms

Synonyms Comment Organism
alpha-glucosidase I
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000017
-
-
 Rattus norvegicus N-(6'-(4''-azido-2''-nitrophenylamino)hexyl)-1-deoxynojirimycin
0.000108
-
-
 Rattus norvegicus N-(6'-(2'',4''-dinitrophenylamino)hexyl)-1-deoxynojirimycin
0.00068
-
-
 Rattus norvegicus N-butyl-deoxynojirimycin