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Literature summary for 3.2.1.106 extracted from

  • Hettkamp, H.; Bause, E.; Legler, G.
    Inhibition by nojirimycin and 1-deoxynojirimycin of microsomal glucosidases from calf liver acting on the glycoprotein oligosaccharides Glc1-3Man9GlcNAc2 (1982), Biosci. Rep., 2, 899-906.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100 activation, maximal at 0.5% Triton X-100 Bos taurus
Triton X-100 several-fold activation Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
1-deoxynojirimycin 0.01 mM: 80% inhibition; strong inhibition Bos taurus
additional information no inhibition by conduritol B epoxide, bromoconduritols a and B, acarbose at 1 mM Bos taurus
Nojirimycin strong inhibition, 0.1 mM: 40% inhibition, 0.16 mM: 50% inhibition Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum rough endoplasmic reticulum Bos taurus 5783
-
membrane membrane-bound Bos taurus 16020
-
microsome
-
Bos taurus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Glc3Man9GlcNAc2 + H2O Bos taurus hydrolyses specifically terminal alpha1,2-linked glucose residue ?
-
?
additional information Bos taurus involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
?
additional information Bos taurus involved in processing of asparagine-linked oligosaccharides ?
-
?
additional information Bos taurus glucosidase I is a control enzyme for the regulation of glycoprotein processing ?
-
?
additional information Bos taurus involved in the formation of high mannose and complex glycoproteins ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
calf
-

Reaction

Reaction Comment Organism Reaction ID
Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose glucosidase I is a specific alpha-(1,2)-glucosidase Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver calf Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Bos taurus D-glucose + Glc2Man9GlcNAc2
-
?
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Bos taurus ?
-
?
Glc3Man9GlcNAc2-lipid + H2O no significant difference in enzyme activity towards free, peptide-bound, or lipid-linked oligosaccharide, lipid- and peptide-linked oligosaccharide are hydrolyzed at a rate only 10% lower than free oligosaccharide Bos taurus D-glucose + Glc2Man9GlcNAc2-lipid
-
?
Glc3Man9GlcNAc2-peptide + H2O no significant difference in enzyme activity towards free, peptide-bound, or lipid-linked oligosaccharide, lipid- and peptide-linked oligosaccharide are hydrolyzed at a rate only 10% lower than free oligosaccharide Bos taurus D-glucose + Glc2Man9GlcNAc2-peptide
-
?
additional information involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Bos taurus ?
-
?
additional information involved in processing of asparagine-linked oligosaccharides Bos taurus ?
-
?
additional information glucosidase I is a control enzyme for the regulation of glycoprotein processing Bos taurus ?
-
?
additional information involved in the formation of high mannose and complex glycoproteins Bos taurus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2
-
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.16
-
Nojirimycin
-
Bos taurus