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Literature summary for 3.2.1.106 extracted from

  • Palcic, M.M.; Scaman, C.H.; Otter, A.; Szpacenko, A.; Romaniouk, A.; Li, Y.X.; Vijay, I.K.
    Processing alpha-glucosidase I is an inverting glycosidase (1999), Glycoconj. J., 16, 351-355.
    View publication on PubMed
Search for more literature for 3.2.1.106

Application

Application Comment Organism
pharmacology enzyme is an inhibitor target for antiviral agents that interfere with the formation of essential glycoproteins required in viral assembly, secretion and infectivity Saccharomyces cerevisiae
pharmacology enzyme is an inhibitor target for antiviral agents that interfere with the formation of essential glycoproteins required in viral assembly, secretion and infectivity Bos taurus
pharmacology glucosidase I may be a target for antiviral and antitumor drugs, glucosidase I inhibitors are potentially useful as antiviral, antitumor and antimetastatic agents Saccharomyces cerevisiae
pharmacology glucosidase I may be a target for antiviral and antitumor drugs, glucosidase I inhibitors are potentially useful as antiviral, antitumor and antimetastatic agents Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Bos taurus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Glc3Man9GlcNAc2 + H2O Saccharomyces cerevisiae hydrolyses specifically terminal alpha1,2-linked glucose residue ?
-
 ?
Glc3Man9GlcNAc2 + H2O Bos taurus hydrolyses specifically terminal alpha1,2-linked glucose residue ?
-
 ?
Glc3Man9GlcNAc2 + H2O Saccharomyces cerevisiae specific involvement in the N-linked oligosaccharide-processing pathway ?
-
 ?
Glc3Man9GlcNAc2 + H2O Bos taurus specific involvement in the N-linked oligosaccharide-processing pathway ?
-
 ?
Glc3Man9GlcNAc2 + H2O Saccharomyces cerevisiae involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
Glc3Man9GlcNAc2 + H2O Bos taurus involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
Glc3Man9GlcNAc2 + H2O Saccharomyces cerevisiae involved in processing of asparagine-linked oligosaccharides ?
-
 ?
Glc3Man9GlcNAc2 + H2O Bos taurus involved in processing of asparagine-linked oligosaccharides ?
-
 ?
additional information Saccharomyces cerevisiae involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
additional information Bos taurus involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
additional information Saccharomyces cerevisiae involved in processing of asparagine-linked oligosaccharides ?
-
 ?
additional information Bos taurus involved in processing of asparagine-linked oligosaccharides ?
-
 ?
additional information Saccharomyces cerevisiae significant role in protein folding by allowing the binding of glycoproteins to the endoplasmic reticulum chaperones calnexin and calreticulin ?
-
 ?
additional information Bos taurus significant role in protein folding by allowing the binding of glycoproteins to the endoplasmic reticulum chaperones calnexin and calreticulin ?
-
 ?
additional information Saccharomyces cerevisiae key enzyme in the biosynthesis of asparagines-linked oligosaccharides catalyzing the first processing event after the en bloc transfer of Glc3Man9GlcNAc2 to proteins ?
-
 ?
additional information Bos taurus key enzyme in the biosynthesis of asparagines-linked oligosaccharides catalyzing the first processing event after the en bloc transfer of Glc3Man9GlcNAc2 to proteins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae
lactating mammary gland Bos taurus

Reaction

Reaction Comment Organism Reaction ID
Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose mechanism Saccharomyces cerevisiae
a
Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose mechanism Bos taurus
a
Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose stereochemistry, enzyme is an inverting glycosidase, operates with inversion of anomeric configuration Saccharomyces cerevisiae
a
Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose stereochemistry, enzyme is an inverting glycosidase, operates with inversion of anomeric configuration Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
mammary gland
-
 Bos taurus
-
mammary gland lactating mammary glands Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Saccharomyces cerevisiae
additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-Glc-(1-2)-alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 + H2O
-
 Saccharomyces cerevisiae beta-D-glucose + alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 formation of alpha-glucose is delayed with respect to beta-glucose: enzyme operates with inversion of anomeric configuration ?
alpha-D-Glc-(1-2)-alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 + H2O
-
 Bos taurus beta-D-glucose + alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 formation of alpha-glucose is delayed with respect to beta-glucose: enzyme operates with inversion of anomeric configuration ?
alpha-D-Glc-(1-2)-alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 + H2O synthetic substrate, formation of the product demonstrates that the enzyme operates with inversion of anomeric configuration Saccharomyces cerevisiae beta-D-glucose + alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3
-
 ?
alpha-D-Glc-(1-2)-alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 + H2O synthetic substrate, formation of the product demonstrates that the enzyme operates with inversion of anomeric configuration Bos taurus beta-D-glucose + alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3
-
 ?
Glc3Man9GlcNAc2 + H2O
-
 Saccharomyces cerevisiae D-glucose + Glc2Man9GlcNAc2
-
 ?
Glc3Man9GlcNAc2 + H2O
-
 Bos taurus D-glucose + Glc2Man9GlcNAc2
-
 ?
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Saccharomyces cerevisiae D-glucose + Glc2Man9GlcNAc2
-
 ?
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Bos taurus D-glucose + Glc2Man9GlcNAc2
-
 ?
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Saccharomyces cerevisiae ?
-
 ?
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Bos taurus ?
-
 ?
Glc3Man9GlcNAc2 + H2O specific involvement in the N-linked oligosaccharide-processing pathway Saccharomyces cerevisiae ?
-
 ?
Glc3Man9GlcNAc2 + H2O specific involvement in the N-linked oligosaccharide-processing pathway Bos taurus ?
-
 ?
Glc3Man9GlcNAc2 + H2O involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Saccharomyces cerevisiae ?
-
 ?
Glc3Man9GlcNAc2 + H2O involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Bos taurus ?
-
 ?
Glc3Man9GlcNAc2 + H2O involved in processing of asparagine-linked oligosaccharides Saccharomyces cerevisiae ?
-
 ?
Glc3Man9GlcNAc2 + H2O involved in processing of asparagine-linked oligosaccharides Bos taurus ?
-
 ?
additional information also acts, more slowly, on the corresponding glycolipids and glycopeptides Saccharomyces cerevisiae ?
-
 ?
additional information also acts, more slowly, on the corresponding glycolipids and glycopeptides Bos taurus ?
-
 ?
additional information p-nitrophenyl-glucosides: no substrates Saccharomyces cerevisiae ?
-
 ?
additional information p-nitrophenyl-glucosides: no substrates Bos taurus ?
-
 ?
additional information involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Saccharomyces cerevisiae ?
-
 ?
additional information involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Bos taurus ?
-
 ?
additional information involved in processing of asparagine-linked oligosaccharides Saccharomyces cerevisiae ?
-
 ?
additional information involved in processing of asparagine-linked oligosaccharides Bos taurus ?
-
 ?
additional information significant role in protein folding by allowing the binding of glycoproteins to the endoplasmic reticulum chaperones calnexin and calreticulin Saccharomyces cerevisiae ?
-
 ?
additional information significant role in protein folding by allowing the binding of glycoproteins to the endoplasmic reticulum chaperones calnexin and calreticulin Bos taurus ?
-
 ?
additional information key enzyme in the biosynthesis of asparagines-linked oligosaccharides catalyzing the first processing event after the en bloc transfer of Glc3Man9GlcNAc2 to proteins Saccharomyces cerevisiae ?
-
 ?
additional information key enzyme in the biosynthesis of asparagines-linked oligosaccharides catalyzing the first processing event after the en bloc transfer of Glc3Man9GlcNAc2 to proteins Bos taurus ?
-
 ?