Literature summary for 3.2.1.10 extracted from

Jones, K.; Sim, L.; Mohan, S.; Kumarasamy, J.; Liu, H.; Avery, S.; Naim, H.Y.; Quezada-Calvillo, R.; Nichols, B.L.; Pinto, B.M.; Rose, D.R.
Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase (2011), Bioorg. Med. Chem., 19, 3929-3934.

Search for more literature for 3.2.1.10

Cloned(Commentary)

Cloned (Comment)	Organism
recombinant expression of N-terminally His-tagged enzyme in Drosophila melanogaster S2 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
acarbose	-	Homo sapiens
blintol	selenium analogue of salacinol	Homo sapiens
de-O-sulfonated kotalanol	isolated from Salacia reticulata	Homo sapiens
kotalanol	isolated from Salacia reticulata	Homo sapiens
miglitol	-	Homo sapiens
additional information	inhibition profiles of the individual N- and C-terminal catalytic subunits of the enzyme by clinical glucosidase inhibitors, acarbose and miglitol, and glucosidase inhibitors from an Ayurvedic remedy used for the treatment of type II diabetes, overview	Homo sapiens
salacinol	isolated from Salacia reticulata	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14410	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant N-terminally His-tagged enzyme from Drosophila melanogaster S2 cells by copper affinity chromatography and ion exchange chromatography	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
small intestine	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is active with maltose, maltotriose, and sucrose, only the N-terminal catalytic domain acts as alpha-1,6-glucosidase	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
More	the enzyme belongs to the family 31 of glycoside hydrolases	Homo sapiens
sucrase-isomaltase	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000012	-	de-O-sulfonated kotalanol	N-terminal cataklytic domain, pH and temperature not specified in the publication	Homo sapiens
0.000148	-	miglitol	N-terminal cataklytic domain, pH and temperature not specified in the publication	Homo sapiens
0.00016	-	blintol	N-terminal cataklytic domain, pH and temperature not specified in the publication	Homo sapiens
0.000277	-	salacinol	N-terminal cataklytic domain, pH and temperature not specified in the publication	Homo sapiens
0.0006	-	kotalanol	N-terminal cataklytic domain, pH and temperature not specified in the publication	Homo sapiens
0.014	-	acarbose	N-terminal cataklytic domain, pH and temperature not specified in the publication	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)