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Literature summary for 3.2.1.10 extracted from
- Inhibition of purified human sucrase and isomaltase by ethanolamine derivatives (1996), Biol. Pharm. Bull., 19, 341-344.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Amino-2-ethyl-1,3-propanediol | 80% inhibition of isomaltase activity by 50 mM | Homo sapiens |  |
| 2-amino-2-methyl-1,3-propanediol | almost complete inhibition of isomaltase activity by 50 mM | Homo sapiens | |
| diethanolamine | about 80% inhibition of isomaltase activity by 50 mM | Homo sapiens | |
| Monoethanolamine | about 70% inhibition of isomaltase activity by 50 mM | Homo sapiens | |
| triethanolamine | about 80% inhibition of isomaltase activity by 50 mM | Homo sapiens | |
| Tris | complete inhibition of isomaltase activity by 50 mM | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| brush border | of the small intestinal absorptive cells of the villus and the crypts | Homo sapiens | 5903 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 130000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| oligosaccharide + H2O | Homo sapiens | role in absorption of sucrose, isomaltose, maltose | monosaccharide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
| proteolytic modification | pro-sucrase-isomaltase precursor, complex glycosylated sucrase-isomaltase precursor, high-mannose sucrase-isomaltase precursor | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| alpha-D-glucopyranosyl-(1-4)-[alpha-D-glucopyranosyl-(1-6)]-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranose + H2O = alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranosyl-(1-4)-alpha-D-glucopyranose + D-glucose | enzyme from intestinal mucosa also catalyzes the reaction of sucrase alpha-glucosidase, EC 3.2.1.48 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| small intestine | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.3 | - |
purified enzyme, isomaltose as substrate | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isomaltosaccharides + H2O | n = 2, isomaltose | Homo sapiens | D-glucose | - |
? | |
| isomaltose + H2O | - |
Homo sapiens | 2 D-glucose | - |
? | |
| oligosaccharide + H2O | role in absorption of sucrose, isomaltose, maltose | Homo sapiens | monosaccharide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| isomaltase | - |
Homo sapiens |
| sucrase-isomaltase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Homo sapiens |
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