Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Sorghum procyanidin tetramer | thermodynamics, and binding and inhibition kinetics, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04745 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
salivary gland | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
55.77 | - |
commercial enzyme preparation, solution, pH 6.9, 37°C, in presence of 4 mg/ml Sorghum procyanidin tetramer | Homo sapiens |
110.94 | - |
commercial enzyme preparation, solution, pH 6.9, 37°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | interaction analysis of human salivary alpha-amylase and Sorghum procyanidin tetramer, structure, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-amylase 1 | - |
Homo sapiens |
HSA | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.9 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the glycosyl hydrolase family 13, GH13 | Homo sapiens |
physiological function | as one of receptors of the acquired membrane, human salivary alpha-amylase (HSA) plays an important role in the formation of caries. The conformation of the enzyme is altered in the presence of SPC-tetramer. The conformation changes of enzyme HSA might contribute to the reduction of the adhesion of cariogenic bacteria and finally decrease the occurrence of dental caries. Preventive effect of Sorghum procyanidins on dental caries | Homo sapiens |