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Literature summary for 3.1.8.1 extracted from

  • Ponce-Ruiz, N.; Murillo-Gonzalez, F.E.; Rojas-Garcia, A.E.; Mackness, M.; Bernal-Hernandez, Y.Y.; Barron-Vivanco, B.S.; Gonzalez-Arias, C.A.; Medina-Diaz, I.M.
    Transcriptional regulation of human paraoxonase 1 by nuclear receptors (2017), Chem. Biol. Interact., 268, 77-84 .
    View publication on PubMed
Search for more literature for 3.1.8.1

Application

Application Comment Organism
medicine PON1 activity and expression levels are important for determining susceptibility to organophosphorus compounds intoxication and risk of developing diseases related to inflammation and oxidative stress Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is synthesized primarily in the liver and secreted into the plasma, where it is associates with high density lipoproteins (HDL) Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
paraoxon + H2O Homo sapiens
-
 diethyl phosphate + 4-nitrophenol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P27169
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
additional information the enzyme is synthesized primarily in the liver and secreted into the plasma, where it is associates with high density lipoproteins (HDL) Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
paraoxon + H2O
-
 Homo sapiens diethyl phosphate + 4-nitrophenol
-
 ?

Synonyms

Synonyms Comment Organism
paraoxonase 1
-
 Homo sapiens
PON1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens analysis of the role of nuclear receptors in the regulation of PON1 expression additional information

General Information

General Information Comment Organism
physiological function paraoxonase 1 (PON1) is a calcium-dependent lactonase synthesized primarily in the liver and secreted into the plasma, where it is associates with high density lipoproteins (HDL). PON1 acts as antioxidant preventing low-density lipoprotein (LDL) oxidation, a process considered critical in the initiation and progression of atherosclerosis. Additionally, PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs). Modulation of PON1 expression by many factors is due to interaction with nuclear receptors (NRs) Homo sapiens