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Literature summary for 3.1.8.1 extracted from

  • Erzengin, M.; Basaran, I.; Cakir, U.; Aybey, A.; Sinan, S.
    In vitro inhibition effect of some dihydroxy coumarin compounds on purified human serum paraoxonase 1 (PON1) (2012), Appl. Biochem. Biotechnol., 168, 1540-1548.
    View publication on PubMed
Search for more literature for 3.1.8.1

Inhibitors

Inhibitors Comment Organism Structure
6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one noncompetitive Homo sapiens
6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one noncompetitive Homo sapiens
6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one uncompetitive Homo sapiens
6,7-dihydroxycoumarin uncompetitive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
paraoxon + H2O
-
 Homo sapiens 4-nitrophenol + diethyl phosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0003
-
 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one pH 10.5, 37°C Homo sapiens
0.001
-
 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one pH 10.5, 37°C Homo sapiens
0.008
-
 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one pH 10.5, 37°C Homo sapiens
0.093
-
 6,7-dihydroxycoumarin pH 10.5, 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
 pH 10.5, 37°C Homo sapiens 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one
0.012
-
 pH 10.5, 37°C Homo sapiens 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one
0.022
-
 pH 10.5, 37°C Homo sapiens 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one
0.178
-
 pH 10.5, 37°C Homo sapiens 6,7-dihydroxycoumarin