Protein Variants | Comment | Organism |
---|---|---|
Q192R | a naturally occuring polymorphism, 192QQ, 192RR or 192QR, that reduces PON1 activity and increases the risk of ischemic stroke, genotyping and phenotyping, allele frequency, the paraoxonase/arylesterase activity ratio is unaltered | Homo sapiens |
R192Q | a naturally occuring polymorphism, 192QQ, 192RR or 192QR, that reduces PON1 activity and increases the risk of ischemic stroke, genotyping and phenotyping, allele frequency, the paraoxonase/arylesterase activity ratio is unaltered | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27169 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview | Homo sapiens | ? | - |
? | |
paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
paraoxonase 1 | - |
Homo sapiens |
PON1 | - |
Homo sapiens |