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Literature summary for 3.1.8.1 extracted from
- Age-related paraoxonase activity changes in Turkish population (2007), Ann. N. Y. Acad. Sci., 1100, 218-222.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| distribution of three PON1 polymorphisms in individuals of different age, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lipid particle | the enzyme is associated to HDL | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | PON1 is a high-density lipoprotein-associated enzyme capable of hydrolyzing diverse substrates from organophosphate toxins to oxidized phospholipids, PON1 is linked with both the prevention of organophosphate poisoning and inhibition of atherosclerosis initiated by oxidatively modified low-density lipoprotein, overview, phenotypic distribution of the enzyme in individuals of both sexes and different age, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
individuals of both sexes and different age, overview | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
enzyme activity in individuals of both sexes and different age, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | PON1 is a high-density lipoprotein-associated enzyme capable of hydrolyzing diverse substrates from organophosphate toxins to oxidized phospholipids, PON1 is linked with both the prevention of organophosphate poisoning and inhibition of atherosclerosis initiated by oxidatively modified low-density lipoprotein, overview, phenotypic distribution of the enzyme in individuals of both sexes and different age, overview | Homo sapiens | ? | - |
? | |
| additional information | PON1 is a high-density lipoprotein-associated enzyme capable of hydrolyzing diverse substrates from organophosphate toxins to oxidized phospholipids | Homo sapiens | ? | - |
? | |
| paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| paraoxonase1 | - |
Homo sapiens |
| PON1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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