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Literature summary for 3.1.8.1 extracted from
- Rat liver paraoxonase: subcellular distribution and characterization (1993), Chem. Biol. Interact., 87, 149-154.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ba2+ | - |
Rattus norvegicus |  |
| Co2+ | plasma enzyme more sensitive than liver enzyme | Rattus norvegicus | |
| Cu2+ | plasma enzyme more resistant than liver enzyme | Rattus norvegicus | |
| EDTA | - |
Rattus norvegicus | |
| Hg2+ | - |
Rattus norvegicus | |
| La3+ | - |
Rattus norvegicus | |
| Mg2+ | plasma enzyme more resistant than liver enzyme | Rattus norvegicus | |
| Mn2+ | plasma enzyme more sensitive than liver enzyme | Rattus norvegicus | |
| p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
| Zn2+ | plasma enzyme more resistant than liver enzyme | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.4 | - |
paraoxon | - |
Rattus norvegicus | |
| 0.4 | - |
paraoxon | 37°C, pH 7.4 | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | requirement | Rattus norvegicus | |
| Ca2+ | required for maximal activity | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| two forms, plasma and liver form | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| plasma | - |
Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C or 4°C, plasma enzyme stable, liver enzyme less stable | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| paraoxon + H2O | - |
Rattus norvegicus | diethylphosphate + 4-nitrophenol | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | - |
plasma enzyme stable, liver enzyme less stable | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Rattus norvegicus |
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